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CHLOROPHYL FROM DARK GREEN VEGETABLES MAY BE THE CANCER ANSWER

DARK GREEN VEGES HAVE POWERFUL PROPERTIES AGAINST CANCERS

IS THE GREEN CHLOROPHYL FROM DARK GREEN VEGES THE CANCER ANSWER?

Indole-3-carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol is the subject of on-going Biomedical research into its possible anticarcinogenic, antioxidant, and anti-atherogenic effects. Research on indole-3-carbinol has been conducted primarily using laboratory animals and cultured cells. Limited and inconclusive human studies have been reported. A recent review of the biomedical research literature found that “evidence of an inverse association between cruciferous vegetable intake and breast or prostate cancer in humans is limited and inconsistent” and “larger randomized controlled trials are needed” to determine if supplemental indole-3-carbinol has health benefits[1].

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Indole-3-carbinol and cancer

Investigation of mechanisms by which consumption of indole-3-carbinol might influence cancer incidence focuses on its ability to alter estrogen metabolism and other cellular effects. Controlled studies have been performed on such animals as rats, mice, and rainbow trout, introducing various controlled levels of carcinogens, and levels of Indole-3-carbinol into their daily diet. Results showed dose-related decreases in tumor susceptibility due to Indole-3-carbinol (inferred by decreases in aflatoxinDNA binding). The first direct evidence of pure anti-initiating activity by a natural anticarcinogen (indole-3-carbinol) found in human diet was claimed by Dashwood, et al., in 1989.

In 2006, Hsu et al. proved that indole-3-carbinol induces a  growth arrest of human reproductive cancer cells. This is significant in the prevention and treatment of cancer, as the G1 phase of cell growth occurs early in the cell lifecycle, and, for most cells, is the major period of cell cycle during its lifespan. The G1 phase is marked by synthesis of various enzymes that are required in the next phase, including those needed for DNA replication.

It should be noted that indiscriminate overuse of indole-3-carbinol supplements in the hope of preventing cancer may be unwise, as the hormone balance should be tested (via simple blood test) before regular consumption. Such caution is advised, due to its effect on estrogen levels (estrogen has a significant impact on brain function).

Indole-3-carbinol and Systemic Lupus Erythematosus (SLE)

Indole-3-carbinol can shift estrogen metabolism towards less estrogenic metabolites. SLE (or lupus), a currently incurable autoimmune disease, is associated with estrogen. In a study using mice bred to develop lupus, I3C was fed to one group while another group was fed a standard mouse diet; the group fed the I3C diet lived longer and had fewer symptoms of disease.  Another study of lupus prone mice with I3C defined the mechanism for the improvement of their disease to be due to sequential blocks in the development of B and T cells of these mice. The maturation arrests resulted in a fall in autoantibody production, thought to be a crucial component of lupus causation. In addition, I3C supplementation of the disease prone mice led to a normalization of their T cell function.  Women with lupus can manifest a metabolic response to I3C and might also benefit from its antiestrogenic effects. Clinical trials are currently underway to determine the efficacy of treating human patients suffering from lupus with I3C.

Dietary sources

Indole-3-carbinol occurs naturally in cruciferous vegetables such as cabbage, broccoli, brussels sprouts, and kale. It is also widely available in supplement form.

Sourced and published  by Henry Sapiecha 27th April 2010

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