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Archive for November, 2011

ALZHEIMERS REVERSAL ON THE CARDS WITH INJECTION

Monday, November 7th, 2011

DOES THIS INJECTION REVERSE ALZHEIMERS?

A new study pinpoints the importance of certain soluble proteins, called cytokines, in Alzheimer’s disease. The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a very critical component of the brain’s immune system. Normally, TNF finely regulates the transmission of neural impulses within the brain. The authors hypothesized that elevated levels of TNF in Alzheimer’s disease interacy adversely with this regulation. To reduce elevated TNF, the authors gave patients an injection of an anti-TNF therapeutic called etanercept. Excess TNF-alpha has been documented in the cerebrospinal fluid of patients with Alzheimer’s.

The new study documents a dramatic and unprecedented therapeutic effect in an Alzheimer’s patient: improvement within minutes following delivery of perispinal etanercept, which is etanercept given by injection in the spine. Etanercept (trade name Enbrel) binds and inactivates excess TNF. Etanercept is FDA approved to treat a number of immune-mediated disorders and is used off label in the study.

The use of anti-TNF therapeutics as a new treatment choice for many diseases, such as rheumatoid arthritis and potentially even Alzheimer’s, was recently chosen as one of the top 10 health stories of 2007 by the Harvard Health Letter.

Similarly, the Neurotechnology Industry Organization has recently selected new treatment targets revealed by neuroimmunology (such as excess TNF) as one of the top 10 Neuroscience Trends of 2007. And the Dana Alliance for Brain Initiatives has chosen the pilot study using perispinal etanercept for Alzheimer’s for inclusion and discussion in their 2007 Progress Report on Brain Research.

The lead author of the study, Edward Tobinick M.D., is an assistant clinical professor of medicine at the University of California, Los Angeles and director of the Institute for Neurological Research, a private medical group in Los Angeles. Hyman Gross, M.D., clinical professor of neurology at the University of Southern California, was co-author.

This study is accompanied by an extensive commentary by Sue Griffin, Ph.D., director of research at the Donald W. Reynolds Institute on Aging at the University of Arkansas for Medical Sciences (UAMS) in Little Rock Arkansaw and at the Geriatric Research and Clinical Center at the VA Hospital in Little Rock, who along with Robert Mrak, M.D., chairman of pathology at University of Toledo Medical School, are editors-in-chief of the Medical Journal of Neuroinflammation.

Griffin and Mrak are pioneers in the field of neuroinflammation. Griffin published an extensive landmark study in 1989 describing the association of cytokine overexpression in the brain and Alzheimer’s disease. Her research helped pave the way for the findings of the present study. Griffin has recently been selected for membership in the Dana Alliance for Brain Initiatives, a nonprofit organization of more than 200 leading neuroscientists, including ten Nobel laureates.

“It is unprecedented that we can see cognitive and behavioral improvement in a patient with established dementia within minutes of therapeutic intervention,” said Griffin. “It is imperative that the medical and scientific communities immediately undertake to further investigate and characterize the physiologic mechanisms involved. This gives all of us in Alzheimer’s research a tremendous new clue about new avenues of research, which is so exciting and so needed in the field of Alzheimer’s. Even though this report predominantly discusses a single patient, it is of significant scientific interest because of the potential insight it may give into the processes involved in the brain dysfunction of Alzheimer’s.”

While the article discusses one patient, many other patients with mild to severe Alzheimer’s received the treatment and all have shown sustained and significently marked improvement.

The new study, entitled “Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration,” and the accompanying commentary, entitled “Perispinal etanercept: Potential as an Alzheimer’s therapeutic,” are available on the Web site of the Journal of Neuroinflammation (http://www.jneuroinflammation.com/content/5/1/2/abstract).

Author Hyman Gross, M.D., has no competing interests. Author Edward Tobinick, M.D. owns stock in Amgen, the manufacturer of etanercept, and has multiple issued and pending patents assigned to TACT IP LLC that describe the parenteral and perispinal use of etanercept for the treatment of Alzheimer’s disease and other neurological disorders, including, but not limited to, U.S. patents 6015557, 6177077, 6419934, 6419944, 6537549, 6982089, 7214658 and Australian patent 758523.

Sourced & published by Henry Sapiecha

DEADLY KILLER MELONS IN AMERICA CAUSES DEATHS OF 28 PEOPLE

Wednesday, November 2nd, 2011

FOOD CONTAMINATION CAUSES MANY DEATHS IN THE USA

Debbie Frederick hopes that her father’s death in last September in one of the most lethal outbreaks of food-borne illness in U.S. history will force the federal government to increase the safety of the country’s food supply.

It took more than ten years, a series of deadly outbreaks tied to foods like peanuts, spinach and ground beef, as well as a coalition of odd bedfellows — victims, public health advocates and food industry reps — to push through the first major restructure of food safety laws since the 1930s.

Advocates and other experts say the Food Safety Modernization Act (FSMA) signed by U.S. President Barack Obama last January still has shortcomings and ware concerned that it will be watered down through a lack of finances.

The United States by all account has some of the safest food in the world. Still, approximateley one in six people get sick from eating tainted food products each year, according to the  Disease Control and Prevention groups.

“The whole system was built to react to people getting sick” or to discoveries of contaminated food, said Erik Olson, the Pew Health Group’s director of food programs.

The U.S. Food and Drug Administration, which regulates allmost all of the U.S. food supply, including melons and other produce, requires major structural changes to become primarily focused on prevention, as FSMA envisions. While lawmakers recently have given FDA more money for food programs, it still has a lot of catching up to do, Olson said.

Eighty-seven-year-old William Beach, Frederick’s father, lived in Oklahoma and was one of the 28 people killed by listeria infection after eating cantaloupe contaminated in what regulators called an “unsanitary” Jensen Farms packing plant in Colorado.

“My father was terrified … nobody should have to go like that,” said Frederick, a Phoenix aesthetician and newly minted activist who is the driving force behind her family’s lawsuit against Jensen Farms. “The system broke down. It shouldn’t have happened. This is very much a preventable thing.”

Herb Stevens, of suburban Denver, also became ill after eating tainted cantaloupe, but had survived. The World War Two veteran, 84, lived at home with his wife before falling ill and now requires full-time care.

“We’d like to see better food safety laws and more inspectors,” Jeni Exley, Stevens’ daughter, said in an interview. Her family is suing for current and future medical expenses.

THE TIGER HAS NO TEETH?

FSMA aims to be a step in the right direction.

The law requires FDA to set standards for produce safety and mandates more frequent inspections of domestic and foreign food processing facilities. It also gives FDA stronger enforcement tools, such as mandatory recall authority and the ability to cancrl the registration of a processing plant.

While inspectors from the U.S. Department of Agriculture must be present at meat and poultry plants they regulate during operating hours, FDA had no frequency mandate for inspections prior to FSMA. As a result, lapses of as long as 10 years were not uncommon.

All high-risk domestic facilities, or those that handle foods with a high potential to cause harm, must be inspected within five years of enactment and no less than every three years thereafter, according to the FDA. In addition, the law rapidly steps up the number of required inspections for foreign facilities.

Jeff Almer and Randy Napier, who lost their mothers to the salmonella outbreak blamed for killing nine people and sickening 700 others who ate contaminated products from Peanut Corporation of America (PCA) in 2008 and 2009, fought to get FSMA passed and now are pushing more FDA funding.

“The needs are substantially greater than what is covered by current funding,” said Steven Grossman, deputy executive director of the Alliance for a Stronger FDA, which said FDA’s food funding rose $52 million to $836 million in fiscal 2011.

The U.S. House of Representatives wants to cut that funding to $750 million in fiscal 2012, while the Senate is proposing increasing funding to $867 million. It is still not known where the final number will come out.

The issue is personal for Almer and Napier, who frequently work with reporters and button-hole lawmakers.

PCA, now bankrupt, is accused of knowingly shipping contaminated products in violation of federal law. The men want to see company President Stewart Parnell criminally charged & convicted.

Handing down an indictment of Parnell would “send a loud and clear message to producers of food to literally clean up their acts,” Almer said.

“We believe there is absolutely no basis for criminal prosecution,” said Parnell’s attorney Bill Gust, a partner at – Gentry Locke Rakes & Moore.

Napier said he has made at least six trips to Washington, D.C., since his mother’s death. Almer testified before Congress in 2009 and said he met with federal law enforcement representatives regarding the PCA criminal case.

Sourced & published by Henry Sapiecha

AYAHUASCA HAPPY JUICE PLANT FROM THE AMAZON JUNGLE ATTRACTS VISITORS FROM ALL OVER THE WORLD

Tuesday, November 1st, 2011

MIND BENDING POTION FOR BLISSFUL HAPPINESS FROM THE AMAZON

MEDICINAL PLANT

AYAHUASCA

The mighty Amazon River holds many mysteries and secrets but you wouldn’t think of it as a place where Western visitors go to transform their lives. Along with countless natural herbal remedies, there’s the apparently magical potion known as Ayahuasca. This mind-bending drug draws people from all over the world..

Works for some people to get off alcohol addiction it is said.

Sourcd & published by Henry Sapiecha