Archive for March, 2013


Friday, March 29th, 2013


This morning, like every weekday morning, I showered, dressed, popped a cognitive-enhancement pill, and headed to the office. My brain drug of choice these days is Concerta, a long-acting form of the popular ADHD drug Ritalin. I’ve also taken Adderall in the past. As far as I can tell, one works about as well as the other. The drugs enable me to work more diligently and in longer spurts than I could otherwise. On any given day, they also drastically increase the chances that I will remember to do things like enter an appointment on my calendar, run an errand on the way home, and respond to emails in a timely fashion.

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 The drug itself, however, does not draw the same bright line. And neither do a growing number of high-achieving, non-ADHD users who see it as the perfect cognitive-enhancement drug—a way to work more, sleep less, and get a better handle on their busy lives.

In today’s competitive economy, some might label that cheating, akin to athletes taking anabolic steroids to gain an unfair edge. Others might suspect that nonprescription Adderall users are only cheating themselves—that the drug won’t really help you if you don’t have ADHD, or that deleterious side effects will counteract any short-term advantages the drug may confer. Perhaps it will even turn out to be seriously harmful. If that’s true, the current frenzy might turn out to be short-lived. But what if it isn’t? What if the neuro-enhancement craze is just getting started? – Home of the best teen driver education course in California. Get your DMV certificate of completion of driver education quickly and easily. Great quality at a good price. Top notch customer service and automatic certificate processing. First course approved by California DMV and only course created with the Driving School Association of California.

Adderall is hardly the first prescription medication to find a black market among the tired and ambitious. As Joshua Foer noted in a Slate story in 2005, Jack Kerouac wrote On the Road while dosed up on Benzedrine, a stimulant that was once prescribed as a nasal decongestant. And for his series on human enhancement technologies 10 years ago, Slate’s David Plotz experimented with Provigil, an alertness drug typically prescribed as treatment for narcolepsy. (More on that below.)

But the prevalence of ADHD—about one in 10 children in the United States meet the diagnostic criteria, according to a recent survey—and the popularity of Ritalin and Adderall for treatment mean that they are far more widely available than other types of brain drugs. That’s especially so because inexpert doctors have a hard time distinguishing a patient who has ADHD from one who’s faking the symptoms to get a fix.

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Some people take the prevalence and subjectivity of the symptoms to mean that ADHD is not even a real disorder—that it’s simply an excuse for lazy parents to medicate their kids. It’s true that the disorder lies on a spectrum, as opposed to something like juvenile diabetes that you either have or you don’t. But as psychiatric disorders go, ADHD is in fact “quite discrete and very diagnosable,” says Scott Kollins, director of the ADHD program at Duke’s medical school. “It’s just not easy to diagnose within 15 minutes,” the length of a standard primary-care doctor visit. In a health care system that isn’t set up to reward careful psychiatric evaluations, some doctors simply shrug and write out the prescription. Others, wary of being played for fools, refuse prescriptions to patients who could really use them.

By law, Adderall is a controlled substance, in the same class as cocaine and methamphetamine. But many of the college students who are taking it don’t see it that way, says Alan DeSantis, a sociologist at the University of Kentucky who studies the culture of ADHD drug use on campus. He got interested in the topic a decade ago while conducting research for a book on fraternities and sororities. “I was asking students about drugs, and they kept saying something very interesting. They kept saying, ‘I don’t do drugs, but I do Adderall.’ ” The difference, in the students’ minds, is that drugs are bad for you and make you unproductive. They view Adderall more like a study aid, DeSantis says, and talk about it openly. In his surveys, up to 50 percent of University of Kentucky upperclassmen have reported using ADHD stimulants at one time or another, most often to cram for midterms or finals.
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To some, those numbers are cause for alarm. “The evidence is pretty clear that these are potent stimulants,” says Craig Rush, a professor of behavioral science at Kentucky. “They produce euphoria, and they have significant abuse potential.” Nora Volkow, director of the National Institute on Drug Abuse, told 60 Minutes in 2010 that she believes even casual use can lead to addiction. “It’s not worth the risk to be playing with a drug that has potentially very adverse affects.” Perhaps the most alarming portrayal of Adderall came in the form of a front-page New York Times article on Feb. 3, which gave the ADHD drug a starring role in the harrowing tale of a once-promising college graduate named Richard Fee who spiraled into depression, mental illness, and ultimately suicide.

Yikes! But wait: If ADHD drugs are highly addictive, even deadly, then why don’t we hear more horror stories of Adderall addicts or overdoses? And why do the same experts who warn about the drug’s dangers say it’s fine for people like me to take it every day? Am I so expendable?

In fact, there is scant evidence that Adderall is physically addictive or dangerous if used responsibly by adults. Its side effects—which can include dizziness, weight loss, and increased heart rate—are real and worth watching out for. People with cardiovascular conditions in particular could have an adverse response, which is one good reason why people should think twice before taking the drug without consulting their doctor. And as with pretty much any medication, crushing and snorting Adderall to get high, or taking more than the recommended dose, is patently foolish. But the drug appears to be far safer on the whole than legal substances like alcohol and nicotine. Even that terrifying Times article, if you read it to the bitter end, acknowledges that “almost every one of more than 40 ADHD experts interviewed for this article said that worst-case scenarios like Richard Fee’s can occur with any medication.”
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The double standards implicit in the warnings about off-prescription use might lead you to think that the drug somehow acts differently on the ADHD brain than it does on the non-ADHD brain—that what’s soothing to one is likely to be either ineffectual or outright harmful to the other. But those who have studied the issue carefully, including Volkow, know that’s not quite right. Ritalin, Adderall, and their chemical cousins work in part by increasing the brain’s access to dopamine, a neurotransmitter that helps control the brain’s pleasure and reward centers. For people with ADHD, that could mean the ability to concentrate on tasks that would otherwise be painfully boring. And for people without ADHD … it could mean the same thing.

Kollins, of the Duke ADHD Clinic, has studied the effects of stimulant drugs on people with and without ADHD and concluded that the differences are largely a matter of degree. “Because patients accurately diagnosed with ADHD are coming into the game at a different baseline as far as what’s going on in their brain, the drugs might sort of bring them back up to a level playing field,” he says. “For somebody without ADHD, because they’re already functioning at that level, it’s going to take them a little bit higher.”

How useful that extra boost is may depend on the task at hand. In an essay in N+1 several years ago, a non-ADHD Adderall user wrote that the drug worked wonders when it came to plowing through philosophy textbooks. But, she said, “I had to be careful not to take the drug in my dorm room, because if I did, I might spend hours plucking my eyebrows or digitally altering photographs.” Martha Farah, a psychologist at the University of Pennsylvania, found in one experiment that non-ADHD subjects who took stimulants saw no performance gains on a series of tests that measured things like creativity and working memory. They only thought the drug was helping them. Other studies have shown modest performance gains. Much remains unknown, partly because the mere mention of ADHD drugs as enhancement is taboo in many medical circles. (A controversial 2008 op-ed in Nature made a strong case that breaking down this research taboo would make everyone safer and better-informed.)
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What’s undeniable is that stimulants allow both ADHD and non-ADHD people to stay alert and focused long past the time they’d normally become distracted or fall asleep. Used in that way, it’s not much different from Provigil, the alertness drug for which Plotz served as Slate’s guinea pig back in 2002. “I am not exactly wired,” he wrote of the experience, “but I’m more alert, more focused, more Plotz-like. Today I’m my own Superman.” But, he added in a cautionary conclusion, “I’d be afraid to make it a habit. I’ll use it again for a special occasion.”

I asked Plotz whether he ever finished that little stash he had tucked into the back corner of his medicine cabinet. He told me that he did—one at a time, here and there. Eventually, he went back for more. To this day, he keeps a few in his house and pops one occasionally for a pick-me-up. But he says he’s never been tempted to binge or begin using the drug on a regular basis.
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Is the use of brain drugs by healthy professionals cheating, like the use of performance-enhancing drugs by athletes? If it gives them an unfair advantage in the workplace, that could put pressure on others to take drugs themselves just to keep up. But unlike steroids, prescription stimulants don’t have clear, drastic long-term health impacts. And while the drugs can be life-changing for people with ADHD, especially kids who would otherwise be totally lost in the classroom, their long-term benefits for those without the disorder are murky. As useful as they may be during the occasional deadline crunch, no study has linked Ritalin or Adderall use in people without ADHD to sustained increases in things like grades or performance reviews.

Forget steroids, then. Here’s an alternative analogy, less alarmist but perhaps unsettling in its own right. What if Adderall turns out to be the new coffee—a ubiquitous, mostly harmless little helper that enables us to spend more time poring over spreadsheets and less time daydreaming or lolling about in bed? For those of us whose natural predilections are to spend far too little time poring and far too much daydreaming, they’re a big improvement over self-medication via caffeine or cigarettes. But those without ADHD might well ask themselves: Don’t I work enough already?

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Friday, March 22nd, 2013
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Detection of cancer cells in blood is important for diagnosis and monitoring of tumors. Scientists at SRI International have identified new predictive protein biomarkers on tumor cells using a Fiber-Optic Array Scanning Technology (FAST) laser that scans 25 million white blood cells per minute.

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Sunday, March 10th, 2013

How Brain Training Can Make

You Significantly Smarter

As many people hit middle age, they often start to notice that their memory and mental clarity are not what they used to be.  We suddenly can’t remember where we put the keys just a moment ago, or an old acquaintance’s name, or the name of an old band we used to love.  As the brain fades, we euphemistically refer to these occurrences as “senior moments.”

While seemingly innocent, this loss of mental focus can potentially have a detrimental impact on our professional, social, and personal well-being.

It happens to most of us, but is it inevitable? 

Neuroscientists are increasingly showing that there’s actually a lot that can be done.  It turns that the brain needs exercise in much the same way our muscles do, and the right mental workouts can significantly improve our basic cognitive functions.  Thinking is essentially a process of making neural connections in the brain.  To a certain extent, our ability to excel in making the neural connections that drive intelligence is inherited.  However, because these connections are made through effort and practice, scientists believe that intelligence can expand and fluctuate according to mental effort.

Now, a new San Francisco Web-based company has taken it a step further and developed the first “brain training program” designed to actually help people improve and regain their mental sharpness.  Called Lumosity, it was designed by some of the leading experts in neuroscience and cognitive psychology from Stanford University.

Lumosity, is far more than an online place to exercise your mental skills.  That’s because they have integrated these exercises into a Web-based program that allows you to systematically improve your memory and attention skills.  The program keeps track of your progress and provides detailed feedback on your performance and improvement.  Most importantly, it constantly modifies and enhances the games you play to build on the strengths you are developing–much like an effective exercise routine requires you to increase resistance and vary your muscle use.

Does it work?

Apparently it does. In randomized, controlled clinical trials, Lumosity was shown to significantly improve basic cognitive functions. One study showed students improved their scores on math tests by 34 percent after using Lumosity for six weeks, significantly greater gains than those made by other students in the same class, who were not training with the Lumosity program.

The company says its users have reported clearer and quicker thinking, improved memory for names, numbers, directions, increased alertness and awareness, elevated mood, and better concentration at work or while driving.

While many of the games at Lumosity are free, a modest subscription fee is required to use the full program over the long term.

However, Lumosity is currently offering a free trial of their program to new users so that you can see how well it works before you decide to subscribe.  The trial is completely free (no credit card required) and the company believes the results will speak for themselves.

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Click here to try for yourself.