Archive for August, 2014


Monday, August 25th, 2014

family shadow symbol image

It’s a good question. The simple answer is threefold:

  • We don’t know what causes brain cancer
  • Current treatments are not good enough
  • We don’t have enough money for research to change this

But in addition, there are specific issues to deal with in paediatric or childhood cases.

Let’s start with the cause: the fact is we don’t know what causes children to develop brain cancer, or adults for that matter. There are various theories, from genetic mutations to epigenetic or environmental factors to viral infections, and research is continually making new discoveries which improve our understanding of the disease. But the more we discover about brain cancer, the more we realise there is still so much more to find out. Take medulloblastoma, for example, which is a common paediatric brain tumour. Because of research and a greater understanding of how brain cancer operates on a molecular level, what was previously thought of as one type of brain cancer is now known to have at least four genetic sub-types, which all require different treatments. As we discover more about the disease, we discover there are even more questions to answer regarding how to treat it.

As well as genetic mutations there are epigenetic factors to consider. A recent Australian study found that fathers working in jobs where they are regularly exposed to benzene in the year before their child is conceived are more than twice as likely to have that child develop a brain tumour. Women working in occupations that expose them chlorinated solvents – found in degreasers, cleaning solutions, paint thinners, pesticides and resins – at any time in their lives also have a much higher risk of their child developing a brain tumour. The researchers stressed that it’s still too early to say whether solvent exposure causes brain tumours. But it is an example of research pointing to epigenetic factors in the development of brain tumours, and specifically the vulnerability of children to brain cancer even before they are born. What we suspect at this stage is that it is likely to be a combination of genetic and environmental factors that lead to increased risk.

The next thing to consider is how effective treatments for children with brain cancer are. The answer: not effective enough. In fact, the internationally recognised expert in childhood brain cancer, Dr Nick Gottardo, describes current treatments as “woefully ineffective”.

Brain cancer is different in children than in adults. There are forms which more commonly affect kids, such as medulloblastoma. But even when typically adult tumours such as high grade gliomas do occur in children, they present very differently on a molecular level.


“They look the same under the microscope, but molecularly they are very distinct diseases….Having more information on these tumours can only benefit us in being able to choose more rational therapies in the near future.”

– Dr. Nick Gottardo

Again, we don’t know why children manifest their own versions of this disease. And some paediatric brain tumours, such as DIPG (Diffuse Intrinsic Pontine Glioma) are brain-stem based and therefore usually inoperable; with the limited treatments available, without surgery, the prognosis is very bleak.

Plus, children’s brains are still developing so the standard treatments for brain cancer, which include surgery, radiotherapy and chemotherapy, can result in more substantial and permanent side effects than they would for an adult. This is a massive problem with childhood cases; applying treatment is harder than in the case of adults. Hence a major consideration when developing new treatments for paediatric brain cancer is how to provide quality of life as well as increasing survival.

“We’re all aiming for 100%, that’s our goal – to cure all children. But we also want to cure them, leaving them with a good quality of life in the long term.”

– Dr. Nick Gottardo

Research funded by The Brain Tumour Charity in the UK has been investigating ways to improve quality of life for children diagnosed with a brain tumour. The team at the University of Southampton collected data on children surviving a brain tumour, including looking at the use of an alternative radiotherapy technique called hyperfractionated radiotherapy, which involves dividing the total dose of radiation into a larger number of smaller doses or fractions, to decrease the effect of the radiation on other tissues, such as the brain. The clinical trial was run by the European International Society for Paediatric Oncology and found that hyperfractionated radiotherapy had less of an impact on children’s memory, planning and organisational skills than conventional radiotherapy. The team says this is an example of how adjusting radiation dose can help reduce side effects while still treating the tumour. In a separate study the researchers looked into different tumour types and observed that different tumours have an impact on quality of life. Furthermore, tumour sub-type is important, with children with medulloblastoma tumours containing the ‘sonic hedgehog’ gene experiencing a better quality of life after treatment than those with other medulloblastoma sub-types. This is the first time that tumour biology has been related to quality of life in medulloblastoma sub-types.

“What we want to do is find new therapies that will be more specific against the tumour and with fewer side effects, so that the children are cured and also cured with excellent quality of life in the future”.

– Dr. Nick Gottardo

The next problem is not insignificant, but nor is it insurmountable: funding. Survival rates for brain cancer have hardly changed in 30 years and remain far too low, with only 2 in 10 people surviving for 5 years. The reason for this – and by association, the reason why brain cancer kills more children than any other disease in Australia – is largely that not enough money has been invested in research. Cure Brain Cancer is doing things differently to improve outcomes for patients and one of things that makes us different is our approach and outlook. Our question is not ‘why?’ but ‘why not?’ and – more importantly – ‘how can we?’ Perhaps this is the more pertinent question here; not why brain cancer kills these children, but how are we going to change this

Research into paediatric brain tumours has come a long way already. Yes, there is a long way to go; survival rates for brain cancer have hardly improved for 30 years. But that’s not because nothing has been done. However, the number of clinical trials for children and access to these trials is limited; with a disease of such low incidence, the clinical research has historically tended to follow what has been done in adult trials, but this is changing.

Professor Stewart Kellie, a paediatric neuro-oncologist & oncologist at The Children’s Hospital at Westmead, says there have already been huge advances, but says global collaboration is key to success when it comes to paediatric clinical trials and research. By pooling resources, answers can be arrived at more quickly.

“I think the biggest change that I’ve seen in my professional career has been the incorporation of research – and particularly clinical trials – into the frontline treatment of children”.

– Prof. Stewart Kellie

Back in April, four international studies made breakthroughs simultaneously in a fatal form of brain cancer, Diffuse Intrinsic Pontine Glioma (DIPG). All of them focused on mutations in the ACVR1 gene. (We published an article at the time looking in more detail at these studies.) Discovering these links between ACRV1 and DIPG opens up many more questions, but that’s not necessarily a bad thing, because it also opens up many more possibilities. One of those studies, led by scientists at the Institute of Cancer Research in London, identified recurrent activating mutations in the ACVR1 gene in DIPG, but also found that those mutations are identical to ones found in people with the congenital childhood developmental disorder fibrodysplasia ossificans progressiva (FOP). What this means is that they can start to investigate whether drugs that have already been developed for FOP could be repurposed to treat DIPG. By discovering common gene mutations between paediatric brain cancer and other diseases or cancers, new treatment options present themselves. This discovery was made possible in part because of international collaboration.

Access to children’s tissue samples to facilitate research is also vital, not just because it can provide insights into that particular patient’s tumour, but because developing tissue banks enables researchers to compare and cross reference data from across brain tumours and across other cancers and diseases. In a recent blog for Cure Brain Cancer, Barrie Littlefield, whose own daughter died from glioblastoma in 2011, said he thinks quick and accurate tumour pathology and up-to-date genetic testing should happen regardless of whether there are clear clinical implications, as the information may be useful at a later stage if not immediately. Tissue banks are invaluable resources when it comes to developing new therapies and understanding the molecular biology of brain tumours. Just last week, a study using data from The Cancer Genome Atlas (a large scale genomic sequencing project) suggested that 1 in 10 cancers could be diagnosed more accurately based on genetic makeup, rather than where they occur in the body. The researchers genetically profiled and compared 3,500 samples of tumor tissue and identified 12 sub-types of cancer, only five of which correlated with their tissue-of-origin classifications. The other seven were newly identified genetic subtypes of cancer which affect more than one type of tissue. They say it ultimately provides the biologic foundation for a new era of personalized cancer treatment, in which cancers are diagnosed based on genetics rather than tissue of origin.

As you can see, many questions remain regarding childhood brain tumours. We don’t know why brain cancer occurs. But crucially we need to answer the question ‘how?’ How do we treat this disease? How do we improve survival, as investment in research has done for other diseases such as leukaemia and breast cancer? How do we give children diagnosed with brain cancer a more hopeful prognosis? The urgency and focus is on finding new treatments but epidemiological advances (which have been hampered by low incidence in children thus far) could ultimately be critical, and this too could be unlocked through further research investment and collaboration. Research will answer these big questions. All that’s required is funding.

Don’t let kids fight brain cancer alone
Henry Sapiecha

Family run in Bridge to Brisbane Qld Australia to raise awareness of stomach cancer

Friday, August 22nd, 2014

Stomach cancer death of Tony Worden

Gillian Worden, of Murarrie and her children Charli, 8, and Tate, 6, image

TONY Worden died from one of the “forgotten cancers” but his wife is determined to shine a spotlight on the killer that robbed their two young children of a father.

Mr Worden was only 41, a regular gym-goer and nonsmoker with a healthy diet when doctors discovered an 11cm stomach tumour.

Tony Worden died of stomach cancer in 2013 image

He had no known family history of stomach cancer and died in January last year, just 14 months after the diagnosis.

Tony Worden died of stomach cancer in 2013 and now his family will run in his memory.

His wife Gillian, and their daughter Charli, 8, and son Tate, 6, have entered the 5km event in The Sunday Mail Suncorp Bank Bridge to Brisbane on Father’s Day to raise much-needed research funding for the Gastrointestinal Cancer Institute in Tony’s honour.

Mrs Worden said her husband’s only symptom before diagnosis was reflux, which lasted for about two months before he saw a GP.

“We were expecting it to be a stomach ulcer. We weren’t even considering that it would be anything more sinister than that,” she said.

Mr Worden had chemotherapy followed by radiation to try and shrink the tumour for surgery but doctors deemed the cancer too advanced to operate.

“Stomach cancer just doesn’t attract the same sort of awareness as other cancers,” Mrs Worden said. “There’s such a poor outcome with stomach cancers.”

The family has been struck by serious illness before, when Tate was diagnosed with an optic glioma, a type of brain tumour, when he was just nine months old. He had 18 months of chemotherapy to shrink the tumour and still has six-monthly scans to make sure it has not started growing again.

The Wordens are determined to carry on as Tony would have wanted them to, doing all the things they would have done if he was still alive, including camping trips.

About 23,000 Australians are diagnosed with gastro­intestinal cancers each year, including tumours of the stomach, oesophagus, gall bladder, liver, pancreas and bowel.

In 2007, 9896 people died of GI cancers compared to 2706 with breast cancer and 2938 with prostate cancer.

Henry Sapiecha


1…I am a survivor, they removed a 14cm malignant  tumour from my large bowel, cutting out 24 cm, I wore a Stoma bag for 7 months, had no Chemo or Radiation, they only found mine after I had a hip replacement and was not making enough Iron, luckily I had a very caring Dr,  I had a reversal done 3 weeks ago, now getting back to a normal life with no Cancer, I have been given the all clear, I am 72 years old, .the first thing that enters your mind  is why me, I was not overweight, I ate healthy, very little Supermarket food, never drank soft drinks, the best thing is to think positive all the time, and my advice is to have regular Colonoscopies, after you turn 50, it will save your life like it did mine. the fact is guys you are not bulletproof

2…My heart goes out to Gillian Charli & Tate & I wish them every success for the future (in particular Tate’s continuing to keeping the brain tumour at bay!) I cannot help but wonder WHY men like Tony wait 2 months before going to a Dr to seek an opinion about a condition that obviously needed addressing! I’ve heard of so many men who just continue on & keep shrugging off symptoms with the attitude ‘She’ll be right mate!’Gentleman PLEASE if a symptom persists for more than a couple of days have it checked out! Not only could it save your life, it will save your family a lifetime of misery!

3…Reflux and Barretts often lead to Oesophageal cancer.. Not big numbers get this cancer and not many survive. I had to get support and information from the US during my husbands battle 10 years ago. He was fit and healthy and lived  only 15 months.  In the US my friends, EC Awareness, are getting states to declare one month a year, Esophageal Cancer month and we should take up this fight too.. it does not discriminate, young or old and it is not a nice cancer either.  Can’t find the Australian figures but they are something like 1600 diagnosed and 1400 die in a year, and few survivors after five years.

4…My sister died from stomach cancer at 40 after 12 months from when she was diagnosed and left behind 6 children the youngest only 2.RIP Janet Glesson nee Single.

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Monday, August 18th, 2014

liver chart

The liver is an essential organ that helps to keep the human body free of toxins. It performs important functions in almost every part of your body, from balancing your cholesterol levels to filtering your blood. Painkillers, prescription medications, alcohol, and other toxins can overload the liver and reduce its ability to function. Detoxing your liver helps to flush out toxins and improve the health of your liver. Here are 7 tips for detoxing your liver.

1. Milk Thistle

milk thistle with purple flower image www.newcures (6)

Milk thistle is a plant that has been used for centuries in order to treat diseases of the liver and gall bladder. Milk thistle contains a compound called Silymarin, which is a potent antioxidant. It is used to reduce inflammation, inhibit the production of toxins, and prevent further damage to the liver. Milk thistle is available as a tincture that can be used to aid the process of a liver detoxification.

2. Apple Cider Vinegar


Apple cider vinegar has been used for thousands of years to treat various ailments and illnesses. It is thought to improve the function of the stomach, colon, liver, bladder, and kidneys. Make your own apple cider vinegar by crushing some fresh apples and filtering the liquid, before allowing it to cure into vinegar. Alternatively, you can buy bottled apple cider vinegar at most health food stores and supermarkets. Use the vinegar to make a warm cleansing drink for your liver by adding 2 tablespoons of apple cider vinegar and one teaspoon of honey to a cup of warm water.

While apple cider vinegar is usually easy and safe to use, there might be some things you’ll want to keep in mind. Since undiluted apple cider vinegar can be harmful to the esophagus and other parts of the digestive tract, you’ll want to be sure to dilute the vinegar. Also, if you are allergic to apples, you will not want to use apple cider vinegar. Try to keep your apple cider consumption to under eight ounces a day as anything over that could potentially decrease potassium levels.

If you have been prescribed certain medications, especially drugs like cardiac glycosides, diuretics, insulin laxatives, diabetes or blood pressure medications, you will want to be careful when using apple cider vinegar. If you are taking these types of medications, it is always good to check with your health care provide before beginning a regimen that could potentially have harmful effects. Even though apple cider vinegar is made from natural sources, it could still interfere with these types of medications.

3. Garlic

garlic images www.newcures (15)

Garlic contains nutrients and Allicin, a compound that helps to aid the process of liver detoxification. Garlic helps to flush heavy metals, nitrogen, and excess hormones from the liver. Cooking garlic can reduce the potency of the nutrients, but the strong flavour of raw garlic can be off-putting for many people. One solution is to try taking garlic capsules, preferably 2-3 times a day while you are performing your liver detox.

When ingesting the garlic capsules, it is best that they are coated so they have a less chance of upsetting your stomach. If your stomach still gets upset when taking a capsule, you can try to take an antacid along with it.

Garlic which is an herb, is normally completely fine for you to use in your detoxification process. However, as with other herbs, there may be some things to keep in mind when using garlic. Although it is not very common, some people have been known to have had an allergic reaction to garlic.

You might want to double check with your health care provider if you are taking certain medications especially for tuberculosis (TB) or HIV/AIDS as garlic can interfere with the absorption of certain kinds of medications specifically for these illnesses. Also for women taking birth control pills, garlic may actually decrease the effectiveness of the pill.

4. Grapefruit seed extract


Grapefruit seed extract contains powerful antioxidants that help to flush toxins from the body, including the liver. Grapefruit seed extract can be expensive, but you only need a few drops 2-3 times a day. If you don’t want to spend money on grapefruit seed extract, try eating a couple of whole grapefruits every day during your liver detox. The results may not be as powerful as using the extract, but grapefruits contain antioxidants that can help to cleanse your liver.

Grapefruit seed extract is processed from grapefruit seeds and pulp and is a byproduct of producing grapefruit juice. In order to reduce the acidity and bitterness of grapefruit juice and extract, vegetable glycerin is added to the final product.

Grapefruit has long been known to interfere with certain medications so it is good to use caution when taking grapefruit seed extract in the detoxification process of your liver. Grapefruit juice has been known to decrease how quickly certain medications are broken down by the liver which can actually increase the side effects of certain medications. You’ll want to be especially cautious if you are taking medications for the following conditions: high blood pressure, high cholesterol, erectile dysfunction and also if you are taking any kinds of sedatives. Other kinds of medications that may have an altered effect when taken with grapefruit are blood thinners such as Coumadin and also medications that contain caffeine.

5. Dandelion Root

Dandelion-flower image

Dandelions are flowering weeds with a wide range of medicinal uses. The roots and leaves of dandelion plants have long been used to make herbal remedies, tinctures and tonics to help cleanse the liver, improve digestion and purify the blood. Dandelions are packed with important nutrients, including calcium, potassium and a variety of vitamins. Dandelion root contains properties that increase the production of bile, which helps to eliminate toxins from the liver.

Dandelion root is available as a tea, tincture, supplement and powdered extract. You can also buy dried dandelion root, which can be prepared in a similar way to fresh coffee. As dandelion root is a powerful diuretic, you must drink plenty of water to replace lost fluids. Dandelion root can also produce a mild laxative effect, making it ideal for flushing out your whole system.

6. Turmeric

Turmeric-powder image

Turmeric is a popular spice that gives curried dishes their striking yellow colour. Turmeric is also commonly used in Ayurvedic and Chinese medicine to treat a wide range of health conditions, including coughs, colds, viruses, infections, irritable bowel syndrome (IBS), Crohn’s disease, high cholesterol levels, excess mucous, nasal congestion and various skin complaints. Turmeric contains powerful anti-inflammatory and anti-spasmodic properties, as well as several health-enhancing nutrients, including iron, copper, potassium, manganese, vitamin B6 and fibre. These powerful properties combine to improve liver function, protect and regenerate liver tissue, aid digestion, reduce digestive gas, reduce cholesterol, boost the immune system, improve circulation and purify the blood. Turmeric is an effective aid for detoxing the liver, particularly when combined with ginger, which helps to boost circulation and reduce congestion. Turmeric is available as a supplement, an extract or a tea.

7. Lemon

Lemon-on white background image

Lemons are packed with vital nutrients, vitamins and minerals, including fibre, vitamin C, vitamin B6, phosphorous, thiamin, riboflavin, copper, calcium, iron, potassium and magnesium. The juice, fruit and peel of lemons are often used in natural remedies and herbal infusions, due to their potent antiseptic, anti-inflammatory, antibacterial and anti-fungal properties. Lemon is commonly used to treat sore throats, tickly coughs, fever, colds, blocked sinuses, indigestion, constipation, tinnitus and rheumatism. Lemon is also thought to help prevent kidney stones, high blood pressure and chronic stomach problems. Lemons contain powerful antioxidants, known as bioflavonoids, which help to cleanse the liver, purify the blood and strengthen the immune system. Adding the juice of half a lemon to a cup of warm water gives you a cleansing drink to help flush toxins from your liver and digestive system. Alternatively, you can buy lemon tea or dried lemons to make a refreshing drink.

8. Green Tea

greentea-in cup image

Lauded as one of the world’s healthiest beverages by both nutritionists and research scientists, green tea is also helpful for detoxing the liver. Green tea originated in China and has long been known in Asia for its many health benefits. Green tea comes from the leaves of the plant called Camellia sinensis. The leaves of the plant are not fermented when being made into green tea which leaves the antioxidant chemicals called polyphenols completely intact. Because green tea is one of the least processed beverages, all of its amazing antioxidants called catechins are nearly poured right into your cup. These catechins which are crucial components when it comes to protecting cells from damage, are also helpful in assisting the liver with the detoxification process.

When you use green tea to detoxify your liver, it is recommended that you drink four to five cups a day. Some people don’t like the taste of green tea and if you still want to experience the powerful detoxification effects of the beverage, you can opt for capsules or liquid supplements. Something to keep in mind regarding green tea is that it does contain caffeine. If you are trying to detox your body from caffeine, you can try drinking decaffeinated green tea. Also, if you take the capsules or supplements, they contain caffeine. It is always best to get the capsules or supplements from a reputable source and you might want to check with your health care provider to ensure they are safe for you to take.

9. Avocados

avocado cut image

Considered a super-food, avocados are rich in nutrients and help the body to produce a compound called glutathione which is necessary for the liver to get rid of harmful toxins in the body. If you have chronic liver disease, your body is probably low on glutathione. Eating avocados can help increase this important compound and help to heal the liver.

Avocados, which are technically a fruit since they grow on a tree and reproduce with a seed, may get a bad rap at times because of their high fat content. However, the fat contained in avocados is monounsaturated and is the healthy fat good for maintaining health cholesterol levels. Avocados also provide about 20 vitamins and minerals that are essential for optimum health. If you consume avocados, you are also helping your body to absorb fat-soluble nutrients. Avocados are a great source of Vitamin C and Vitamin E and antioxidants that help to neutralize free radicals in the liver which can further protect liver cells and keep this vital organ free from harm.

Avocados are eaten in a variety of ways and can replace foods that aren’t so good for you like mayonnaise, sour cream and butter. They taste great on sandwiches, in salads or topped with fresh salsa. Whether you mash them, whip them, slice or dice them, avocados are a great food to eat during the liver detoxification process. They are one food you will want to keep on eating after your detox to help protect and heal the liver.

10. Cabbage

sliced cabbage & juice image

Eating cabbage, which is considered one of the world’s healthiest foods, contains glucosinolate that helps to stimulate the activation of important detoxifying enzymes known to flush out toxins from the liver. There are many foods in the cabbage family including Brussels sprouts, broccoli and cauliflower that can also be good when detoxing the liver. These foods contain sulfur which is known as a cleansing mineral. More importantly, cabbage and the other foods in its family are full of sulfur-containing amino acids. These amino acids, including taurine, methionine and cysteine are essential when it comes to clearing the pathways during a liver detox. If you are eating a lot of cabbage and other vegetables that contain sulfur, you may want to note that eating a lot of fruit might cancel out those benefits since eating fruit can interfere with sulfur metabolism.

While a variety of cabbage can be eaten during a liver detox, only green cabbage contains high amounts of chlorophyll which is known to be important for strengthening the liver. Cabbage is a cruciferous vegetable which also contains Vitamin K, Vitamin C, folate and Omega 3 fatty acids which are all beneficial for optimum health. In order to get the best benefit, be sure to eat organic, raw cabbage. You can also drink raw cabbage juice as a way to detox your liver. If you juice the cabbage yourself, you will want to be sure to drink the juice right away or else it will lose pertinent vitamin content.

11. Walnuts

walnuts image

You might not think of eating nuts as a way to help detox your liver but they contain high density lipoproteins that help to protect against fatty liver disease. These lipoproteins also reduce levels of C-reactive protein that helps to lower inflammation in the liver. This is important because inflammation of the liver is often a precursor to liver damage.

Some nuts, especially walnuts, contain large amounts of the amino acid known as arginine which help to rid the liver of harmful toxins like ammonia. Walnuts also contain high amounts of glutathione and omega-3 fatty acids which are both necessary for effectively detoxifying the liver. One important thing to remember about eating walnuts during a detox is that you want to chew them well, turning them into liquid before swallowing. Because walnuts are a food with low levels of toxicity, extracts from the hulls of walnuts are often used in special formulas made to cleanse the liver from toxins. Protein, antioxidants and healthy unsaturated fats can also be found in walnuts and are all essential for liver health and function. Unsaturated fats are especially important as they help to protect the liver against fat accumulation and aid in building healthy cell membranes around liver cells.

Other nuts that can be healthy for the liver include Brazil nuts, pecans and almonds. Peanuts are usually not a good food when it comes to liver health. When eating nuts for health benefits, make sure to only eat them unsalted and in their rawest form.

Henry Sapiecha

13 Symptoms of Bipolar Disorder: Are You Bipolar?

Monday, August 18th, 2014

Bipolar Disorder is a mood disorder that affects many people every day. According to medical professionals, people who suffer from this mood disorder experience episodes of mania, often followed by episodes of depression and vice versa.

The most common symptom associated with bipolar disorder is sudden mood swings. Individuals who are bipolar will experience heightened euphoria and happiness followed by drastic depression and guilt. While mood swings are the most common symptom, they are not the only symptom. There are several other symptoms associated with this condition and many of them contradict each other. Essentially, there are two types of symptoms: manic symptoms and depressive symptoms. Each set of symptoms produce very different types of behavior and are often experienced back to back in a short period of time.

Below you will find a list of bipolar symptoms from various medical sources as well as the type (manic or depressive or both) associated with each:

1. Mood Swings

Type: Manic and Depressive

Mood swings are the most common symptom of bipolar disorder and are a combination of the manic and depressive symptoms. A mood swing is characterized by high levels of positivity followed by high levels of negativity and depression or vice versa.

two faces of bipolar womans image

2. Euphoria 

Type: Manic

A manic episode will present symptoms of euphoria in patients. Sufferers experience a heightened level of happiness and a sense of accomplishment.

man in suit on chair is happy image

3. Rapid Speech

Type: Manic

A good indication that someone is experiencing a manic episode is rapid speech. Patients will suddenly begin speaking extremely quickly for long periods of time.

man moving fast with phone in hand image

4. Racing Thoughts

Type: Manic

Racing thoughts are a common manic bipolar symptom. Individuals will often have a difficult time focusing on one thing and will tend to over-analyze their thoughts.

racing thoughts with confused man image

5. Irritation

Type: Manic and Depressive

Irritation and agitation are common in both manic and depressive episodes. Sufferers are easily irritated by situations they normally wouldn’t be agitated with.

irritable girl with hands on head image

6. Increased Physical Activity

Type: Manic

When a person is experiencing a manic episode they will often have extremely high levels of energy. To help relieve the energy, sufferers often turn to physical activity. If someone suddenly feels the need to exercise excessively to exert energy, it may be an indication of an underlying problem.

guy working out in gym image

7. Careless Use of Drugs/Alcohol

Type: Manic

Sometimes, people suffering from bipolar disorder will turn to drugs and alcohol. Careless use of these substances may be a warning sign of deeper issues.

alcoholic man shadow image

8. Decreased Need for Sleep

Type: Manic

As previously noted, manic episodes often involve large bursts of energy and euphoria. These symptoms can make it incredibly difficult to sleep. An individual experiencing this symptom may require less sleep, but won’t necessarily feel tired or exhausted.

girl in pink waking up in bed image

9. Missed Work 

Type: Manic and Depressive

A common symptom of bipolar disorder is the inability to maintain a schedule. For this reason, many bipolar sufferers will often miss work (or school or other commitments).

woman in bed taking a sickie image

10. Fatigue

Type: Depressive

Contrary to manic symptoms, individuals suffering from a depressive episode will often experience extreme tiredness and fatigue. Wanting to go to bed, staying in bed late, and an overall lack of motivation throughout the day are all signs of bipolar disorder.

man at laptop with concrete block on head image

11. Chronic Pain with No Known Cause

Type: Depressive

Individuals experiencing other symptoms on the list, along with chronic pain with no known cause, may be suffering from bipolar disorder. This pain can present itself throughout many parts of the body including, but not limited to, severe headaches.

woman with hands on head in pain image

12. Sadness/Hopelessness

Type: Depressive

One of the most telltale symptoms of a depressive episode associated with bipolar disorder is an overwhelming feeling of sadness and hopelessness. Individuals can fall into a state of depression and may have noticeably different symptoms than those related to a manic episode (where individuals experience a heightened sense of happiness and euphoria).

woman crouched in despair image

13. Suicidal Thoughts

Type: Depressive

As noted in slide 12, individuals with bipolar disorder will often feel sad and depressed. In extreme cases, they may develop suicidal thoughts and act in a suicidal manner. If these symptoms present themselves, seek medical or professional attention immediately.

drug overdose image

Henry Sapiecha






Saturday, August 16th, 2014

1…Joseph Stalin’s Humanzee Experiments



2…5 Shocking Medical Experiments on Humans


3…10 Disturbing Child Experiments


4…”The Russian Sleep Experiment” |


5…The Human Chimp Part 1


6…The Human Chimp Part 2


7…The Human Chimp Part 3


8…The Human Chimp Part 4


9…The Human Chimp Part 5


10…The Human Chimp Part 6

Hopefully you have found these videos useful to you & give us a good review with a like & support our sponsers.

Henry Sapiecha




Saturday, August 16th, 2014



2…Maggot found in Taiwanese woman’s ear after

she complained about earache


3…World’s Weirdest – Larva Removed from a

Girl’s Scalp


4…Blood Clot – Bizarre ER


5…Massive Head Splinter – Bizarre ER


6…Balloons in the Head | Bizarre ER


7…Growing Up Without A Face


8…Abigail & Brittany Hensel –

The Twins Who Share a Body


9…The Girl Who Never Ate –

Extraordinary People – Documentary


10…Nick Vujicic – No arms no legs no worries –

look at yourself after watching this!


11…The Eight-Limbed Boy – Documentary


12…The Boy Who Sees Without Eyes


13…Tourette’s Syndrome – Life With Tourette’s


14…10 Year Olds – Terri Calvesbert: Extraordinary

People – Documentary – My Shocking Story


15…My Face is Eating Me Alive – Documentary


16…The 46 Year Pregnancy – Documentary


17…Octopus Man – Documentary


18…I Woke Up in a Morgue – Documentary


19…The Boy With The Incredible Brain – Documentary


20…Shwachman – Diamond Syndrome (SDS) –


Hope these above videos have been of value to you, if so give us a like and tell your friends about this site

Henry Sapiecha

Reece Puddington an11year old boy refuses cancer treatment & opts to ‘let go’

Thursday, August 14th, 2014

No cure: Reece Puddington has been battling with neuroblastoma since 2008.

For most 11-year-old boys, Facebook is a way to chat with friends and share photographs – but for Reece Puddington, it was a place to express a more momentous message.

The boy, who has had cancer for more than half of his life, used a status update to announce he had decided to refuse potentially life-prolonging drugs in order to accept his fate and make the most of his final days, at home with his family.

The decision has been a breath of fresh air for Reece. Not to have to go to the hospital means a lot to him.

He told friends via the website that he could no longer face the demands of gruelling treatment and wished to let “nature take its course”.

puddington cancer boy wants to let go image

He wrote: “My mum had always hoped over the last five to six years that she would have the courage to know when enough was enough. After careful consideration, my mum thought that if she was doing it for herself she would keep sending me for treatment as she wouldn’t want to let me go, but if she was doing it for me she’d let me go. Well, she’s letting me go…”

Reece, from Seasalter, Kent was diagnosed in 2008 with neuroblastoma, a cancer of the nervous system which affects about 100 children a year in the UK. His updates on his condition on Facebook have attracted a growing following. In a posting last Thursday, The Beginning of the End, he wrote: “After the latest scan results I was sent home to rest and think over the 2 possible options …

“I could opt for another trial, but this would mean travelling a lot to the hospital and coping with the side effects, but could also hopefully extend my life, or … I could simply do nothing,stay at home and let nature take its course which would lead to me losing my life slightly earlier than if I’d had more treatment.”

puddington bucket list food image

He said he was taking the second option.

His mother, Kay Puddington, who helps write his blog, said: “Reece has been so good, he never moans. He just got tired of the whole regime. So the rest of the family took on board how he felt and we made the decision to end his treatment.

“He would have gone on to new drugs, but the side effects are always sickness, fatigue and nausea.”

She added: “The decision has been a breath of fresh air for Reece. Not to have to go to the hospital means a lot to him.”

After his diagnosis in May 2008, Reece had chemotherapy at the Royal Marsden Hospital, in Sutton, Surrey. The cancer, which had started in a gland near his kidney, went into remission. However, he became ill again in 2012 and his family was told the condition was terminal. It had spread to his bone marrow, chest, the left side of his pelvis and his right thigh bone.

Reece had drawn up a “bucket list”, of things to do before he died. It includes seeing his mother learn to drive so they could take day trips. Mrs Puddington, 40, who is her son’s full-time carer, passed her test when she was 17 but could not afford a car. It meant she and Reece were housebound while her husband Paul, 48, was at work as a sales assistant for supermarket chain Sainsbury’s

Fatigued because of the ongoing treatments have taken their toll. image

She has now learned to drive again. “We haven’t gone on any trips just yet, as Reece has had a rough few days. But we’re hoping to go on a drive along the coast,” she said.

Reece’s list includes a trip to Sun City, South Africa. Mrs Puddington added: “Unfortunately Reece won’t be able to manage the holiday. He has been so brave and I’m so proud of him.”

Reece added: “I’ve been overwhelmed by all the support. It’s really made a difference to me.”

The Telegraph, London

Henry Sapiecha


Thursday, August 14th, 2014

Inspired by a desire to sleep indoors rather than on a park bench, I called her. By some twist of luck, she had a brother who was out of town, who happened to have an empty apartment near the Bastille. I could have the apartment for three months if I wanted. At once I viewed this as both a miracle and a warning: it was the end of the list that had, in my mind, kept me alive – and perhaps the end of me.


I set off at sunrise the next morning, fed by a warm baguette and the subtle light of the city, grey turning to lemon yellow to gold. With light rain as my only company, I walked through Paris until I reached the famous pyramid, splashed with water nymphs in the form of diamond-coloured drops, surrounded by Japanese tourists holding candy-coloured umbrellas. Rain mixed with tears as I sobbed, finally allowing myself to cry for the first time since I’d forced myself off my living room floor all those years ago.

There was no need for a tour, plan or guide. Unlike the rushed tourists who had to chase down the usual suspects in between flights, I had the extravagance of time. That first day I spent with the first sculpture I saw, the Winged Victory of Samothrace. Gazing at this human figure with wings, perched on the edge of a boat, I imagined her taking flight each night after the Louvre closed. And as I sat on the stairwell looking up at her, I realized that this was not the end of me, but rather the beginning of me.


The month went by slowly, like a painting as it takes shape under the hand of a painter with only one canvas and 1,000 ideas, each day layered with new colours and textures.

For 30 days, each morning I would walk through the city, stopping to buy my baguette and coffee, pretending to be offended when the waiter laughed as my grim attempt at French was replaced by sign language. Further on I’d dodge the rubbish trucks and the early morning graffiti artists to get a place in line at a bakery hidden in an alley, where I’d buy a warm croissant from a baker who smelled like cherry pie. When I’d finally arrive at the square of the Louvre, the pickpockets would smile at me in greeting, while the flower seller pushed a nosegay of bruised violets or tiny pink roses into my hands. At the entrance to the Louvre, the staff would wave me in as they squabbled in furious French with the illegal ticket-sellers just outside the doors.

After a few weeks, I could walk into the museum with my eyes closed. I knew the feel of the handrails, slightly worn yet smooth and cool. I heard the sound of the security guards shifting their feet, the hum of vented air, the sigh of shoes walking on marble. Each painting and sculpture seemed to have waited for my arrival, dressed in their finest draperies and gilded frames, like flags in an endless procession of gladness.

The women of the Louvre invited me to walk past the crowds into their private chambers. Teasing. Whispering. Welcoming. The Mona Lisa, small and stained green, her plucked eyebrows raised quizzically at the crowds who came to admire her. Gabrielle d’Estrées caught forever fondling one of her sisters, no doubt wishing she hadn’t. The Marquise de Pompadour, impossibly coiffed and powdered, permanently poised in pastels. La Grande Odalisque, her body stretched before the world, waiting for gossip and visitors. Here were women unapologetic about being women: whole, incomplete, messy, divided, fertile, plump, merchant, slave, prostitute, servant, old, nubile, lost, found, owned, free. I sat before them, held their gaze evenly, without blinking. Our stories were not the same, yet I found myself in each one of them.


On my last day at the museum, I said goodbye to these painted women, who at first had seemed two dimensional and flat but had come to life and become friends. Then I took a different route back to the apartment, and found myself on the banks of the Seine. I walked along the river, my thoughts on that woman who, many years ago, sat in a field and wrote out a list to save her life. I’d carried her list with me around the world, and as I took it out of my bag, my hands shook so badly it seemed as though the paper would take flight.

One last gesture, one last goodbye, one last promise made to that woman who was me so long ago. Her list was finished, and somehow I felt her end had come as well. I held the journal tightly and tore out that final page of my past. I folded it into a small paper boat, and set it on the Seine. It floated, small and white, like a dove, a peace offering to my old self. My eyes followed the little white boat as it moved down the river, past the barges, until it was gone. She was gone, too.

She finally got what she had wanted the whole time: to be free and not defined by cancer.

And I, too, was free. I still am.

Henry Sapiecha

Developing countries to benefit from MPP and Gilead HIV drug licensing agreement

Thursday, August 14th, 2014

Upon approval for use by the US, a generic version of Gilead’s HIV drug TAF will be made available to low- and middle-income countries

drugs & pills in mans hand image

Medicine Patent Pool (MPP), a not-for-profit organization, has partnered with pharmaceutical company Gilead Sciences to produce a generic version of a new HIV treatment drug in India and China that will be distributed in 112 countries. The partnership was announced last week at the AIDS 2014 conference in Melbourne.

One of the most contentious issues in HIV treatment is the price of antiretrovirals and other drugs that can save lives. Patented drugs by pharmaceutical companies are often far beyond the reach of many of the world’s poorest. Though many developing nations may receive the drugs at a cheaper price, this does not apply to middle income countries like Mexico and India, which still have a very large population of the extremely poor.

Earlier this year, pharmaceutical company Gilead came under fire for releasing a Hepatitis C vaccine that costs US$1,000 per pill, or $84,000 for an entire course. Even in the developed world, there is concern that health insurers might shy away from covering the cost of such expensive drugs and instead force patients back to older and less effective drug treatments.

The licensing agreement between Gilead, one of the sponsors of the AIDS 2014 conference, and the MPP will allow India and China to manufacture a cheap, generic version of the company’s new HIV drug tenofovir alafenamide (TAF). The drug is currently undergoing Phase III clinical trials and, shortly after its approval is the US, will be sold in 112 nations that are said to be home to 92 percent of the developing world’s HIV sufferers, including 65 so-called middle income nations.

“This continues MPP’s novel approach of licensing promising new medicines in advanced stages of development or soon after registration to speed delivery to countries most affected by the HIV epidemic,” said Greg Perry, Executive Director of the MPP.

At an AIDS 2014 press conference, Linda Gail-Bekker, president-elect of the International AIDS Society and a doctor with over 20 years treating the disease in South Africa, expressed her gratitude that the five percent royalty paid to Gilead will not include pediatric treatments, which will be free. This has been key feature of previous agreements between MPP and Gilead. She also sees TAF as a worthy alternative to current treatments, with potentially lower side effects.

TAF itself seems to be notable for a few reasons in itself. Doses of TAF may need to be 10 times lower than tenofovir disoproxil fumarate (TDF), a current widely-used HIV drug. According to the MPP and Gilead, the lower dose will eventuate in lower production costs and also possible greater ease in delivering fixed single tablet treatments.

It is also positively associated with bone density and renal safety markers, according to Phase II tests conducted last year and is being studied as a standalone treatment for chronic Hepatitis B, which like Hepatitis C can be a problematic co-infection for many of those living with HIV.

Source: MPP

Henry Sapiecha

Experimental drug compound found to reverse effects of Alzheimer’s in mice

Thursday, August 14th, 2014

Researchers at Yale University have discovered a drug shown to reverse the brain deficits of Alzheimer’s in mice


While there has been progress made in the fight against Alzheimer’s, our understanding of the dispiriting disease remains somewhat limited, with a definitive cure yet to be found. The latest development comes at the hands of researchers from Yale’s School of Medicine, who have discovered a new drug compound shown to reverse the effects of Alzheimer’s in mice.

The team’s research centers on a protein in the brain called STtriatal-Enriched tyrosine Phosphatase (STEP). While STEP is essential to regulating learning and memory, high levels prevent the strengthening of synapses in the brain. This synaptic strengthening is necessary for people to convert short-term memories into long-term memories, therefore disruption of the process can lead to a range of neuropsychiatric disorders, including Alzheimer’s.

The scientists studied thousands of molecules in search of one that would inhibit the negative effects of STEP. They identified the compound TC-2153 and proceeded to examine its efficacy in curtailing the impacts of STEP, observing a reversal of deficits in a number of cognitive exercises, including the mouse’s ability to remember objects it had seen previously.

“A single dose of the drug results in improved cognitive function in mice,” says Dr Paul Lombroso, professor in the Yale Child Study Center and lead author of the study. “Animals treated with TC compound were indistinguishable from a control group in several cognitive tasks.”

The team is now investigating the effects of TC-2153 in rats and non-human primates with cognitive defects to determine whether the compound is effective at improving cognitive deficits in other animal models. If the testing proves successful, the team says it will bring them one step closer to human trials.

The research findings were published in the journal PLOS Biology.

Source: Yale University

Henry Sapiecha