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IVF baby born using the latest revolutionary genetic-screening process

Saturday, May 28th, 2016

Next-generation sequencing could enable IVF clinics to determine the chances of diseases developing in children

David-Levy-and-Marybeth-S-010 with dna selection image www.newcures.info

Baby Connor Levy with his parents David Levy and Marybeth Scheidts

The first IVF baby to be screened using a procedure that can read every letter of the human genome has been born in the US.

Connor Levy was born on 18 May after a Philadelphia couple had cells from their IVF embryos sent to specialists in Oxford, who checked them for genetic abnormalities. The process helped doctors at the couple’s fertility clinic in the US select embryos with the right number of chromosomes. These have a much higher chance of leading to a healthy baby.

The birth demonstrates how next-generation sequencing (NGS), which was developed to read whole genomes quickly and cheaply, is poised to transform the selection of embryos in IVF clinics. Though scientists only looked at chromosomes – the structures that hold genes – on this occasion, the falling cost of whole genome sequencing means doctors could soon read all the DNA of IVF embryos before choosing which to implant in the mother.

If doctors had a readout of an embryo’s whole genome, they could judge the chances of the child developing certain diseases, such as cancer, heart disease or Alzheimer’s.

Marybeth Scheidts, 36, and David Levy, 41, had tried another fertility treatment, called intrauterine insemination (IUI), three times without success before they signed up for IVF at Main Line Fertility clinic in Pennsylvania.

As part of an international study with Dagan Wells, a fertility specialist at Oxford University, the couple were offered NGS to check their IVF embryos for abnormal chromosomes. Abnormal chromosomes account for half of all miscarriages.

The chances of an embryo having the wrong number of chromosomes rises with the mother’s age, and potentially with the father’s. For women in their 20s, one in 10 embryos may have the wrong number of chromosomes, but for women in their 40s, more than 75% can be faulty.

Most of the time, embryos with abnormal chromosomes fail to implant in the womb. Those that do are usually miscarried. The portion that survive to full term are born with genetic disorders, such as Down’s syndrome and Turner syndrome.

After standard treatment at the US clinic, the couple had 13 IVF embryos to choose from. The doctors cultured the embryos for five days, took a few cells from each and sent them to Wells in Oxford for genetic screening. Tests showed that while most of the embryos looked healthy, only three had the right number of chromosomes.

“It can’t make embryos better than they were in the beginning, but it can guide us to the best ones,” said Wells.

Based on the screening results, the US doctors transferred one of the healthy embryos into Scheidts and left the rest in cold storage. The single embryo implanted, and nine months later Connor was born. Details of the study will be given at the European Society of Human Reproduction and Embryology (Eshre) meeting in London on Monday.

“I think it saved us a lot of heartache,” Scheidts told the Guardian. “My insurance covered me for three cycles of IVF. We might have gone through all three without the doctors picking the right embryos. I would not have a baby now.”

A second baby who had the same genetic screening is due to be born next month, after a US couple had IVF at New York University fertility centre.

Doctors can already screen embryos for abnormal chromosomes using a technique called Array CGH, but the procedure adds more than £2,000 to the cost of IVF. Wells said NGS could bring the cost down by a third. To check the number of chromosomes is much simpler than reading all of the DNA accurately.

“It is hard to overstate how revolutionary this is,” said Michael Glassner, who treated the couple at the Main Line Fertility clinic. “This increases pregnancy rates by 50% across the board and reduces miscarriages by a similar margin. It will be much less expensive. In five years, this will be state of the art and everyone who comes for IVF will have it.”

In Britain, doctors are banned from selecting embryos for anything other than the most serious medical reasons. But as scientists learn more about genetic causes of disease, the urge to choose embryos to avoid cancer and other diseases later in life will intensify.

“You can start to have a very scary picture painted if you talk about height and hair colour and so on,” said Glassner. “We have to make sure this is used judiciously.”

The prospect of “designer babies” is remote for now, even if it were made legal. IVF produces only a dozen or so embryos at best, so the odds that one has all the traits a couple desires are very low. “IVF is still expensive and uncomfortable with no guarantee of a baby at the end. I can’t imagine many people wanting to go through the strains of IVF for something trivial,” said Wells.

The Oxford team now plans a large trial of the screening procedure to assess how much it boosts pregnancy rates, and which age groups it benefits the most.

Scheidts still has two screened embryos in cold storage, but has not yet decided whether to use them. “We haven’t even thought about that. We’ll see how the first year goes.”

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Henry Sapiecha


Dead foetus found inside four-year-old boy

Saturday, October 10th, 2015

foetus image www.newcures.info

WHEN a four-year-old boy complained of a stomach ache last week, doctors suspected a tumour.

But they were shocked after a CAT scan revealed the pain was caused by a dead foetus inside his abdomen.

Dr Shirshendu Giri said he operated on the boy, who was from a village in West Bengal, India.

“The dead embryo which had hands, legs, nails and a partially formed head was removed from the child’s body after a long operation,” he told International Business Times. “The boy is all right now, still under close observation.”

Doctors said the boy suffered from the rare medical condition, “foetus in foetu” (baby within a baby), in which a malformed foetus is found in the body of its twin. In the early stages of pregnancy, one of the twin foetuses may absorb the other. The enveloped twin becomes a “parasite” that relies on its host.

The abnormality has an incidence of one in 500,000 live births, with less than 100 reported cases worldwide, according to a 2005 case report in ANNALS Academy of Medicine Singapore.

In June 2009, a man in India named Sanju Bhagat underwent surgery to have a parasitic twin, which he carried inside his body for 36 years, removed. In March 2006, doctors in Pakistan removed two foetuses from inside a two-month-old girl.

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Henry Sapiecha

NEWLY BORN SHEEP CALF HAD HUMAN FEATURES

Monday, October 17th, 2011

Medical experts were horrified the moment a Cesarian section performed on a sheep revealed its young had the body of an animal and the face of a human!

YOUNG LAMB CALF HAD HUMAN HEAD FEATURES

According to reports, Erhan Elibol, a 29-year-old veterinarian in Turkey, says after he delivered the brood it was dead and suffered a rare mutation that give it human features on its face, including eyes, nose and mouth–but with the ears of a sheep.

“I’ve seen mutations with cows and sheep before. I’ve seen a one-eyed calf, a two-headed calf, a five-legged calf,” he told reporters. “But when I saw this youngster I could not believe my eyes.”

It’s speculated that the mutation was caused by improper nutrition.

Another related story.

Australia, Alice Springs there was seen a puppy  in a dog pack belonging to a local aboriginal community which had a head with human features and stood out markedly from the pack. These dogs were reportedly used for sex by some males in the community and it was  suggested that  a possible mutation was created between the black dog and the black aboriginal as a result with the rogue DNA crossing the threshhold limits of the species.

This story was told to me only a few weeks ago by the 2 people who witnessed the dogs features. They are not liars nor prone to stretching the truth.

Does this then raise the possibility of breeding between species of life to create mutations?

Has anybody got similar stories to share with us for posting in this site

If so please forward to .. admin@acbocallcentre.com

Sourced & published by Henry Sapiecha

CUTTING OUT BABIES MAY BE BETTER FOR YOU AND THE BABY???

Saturday, August 13th, 2011

IS CAESAREAN THE WAY TO GO FOR DELIVERING NEW BORNES?

FOR years, women have been labelled ”too posh to push” for choosing caesarean births without medical reasons, but a controversial new study suggests they may be picking a better path for themselves and their babies.

Dr Stephen Robson, an associate professor of obstetrics at Australian National University, is recruiting 1000 pregnant women to test the long-held view that vaginal deliveries are better than caesareans for healthy women with uncomplicated pregnancies.

The study, which requires 500 women choosing a caesarean and 500 planning a vaginal birth, will look at psychological and physical outcomes for the women and their babies, including depression and breastfeeding rates.

Dr Robson said that although an estimated 10,000 Australian women chose to have caesareans each year without medical reasons, no one had ever comprehensively studied their outcomes because research tended to focus on women with problems. ”From a medical point of view, it’s difficult to counsel people because no one can give a reasonable comparison of what the risks are for women who are otherwise healthy,” he said.

Dr Robson said a study published in The Lancet in 2000, which compared caesareans with vaginal deliveries for babies in the breech position unexpectedly found that women in the caesarean group did slightly better overall than women in the vaginal group. The results left doctors around the world wondering if surgical deliveries could be better for healthy women.

”It dawned on people, what if it turns out to be safer to have a caesarean birth if you’re a healthy mother? … What would that mean? How would that affect society? The topic led to great discussion at a meeting I was at recently where one cheeky guy said, ‘Maybe we could do away with labour wards forever and save hundreds of millions of dollars,’ ” he said.

”Depending on what we find, there is a profound sense that maybe this will lead to an unanticipated and staggering finding.”

Current research cited by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists says caesareans in healthy women may reduce the chance of injuries that lead to incontinence and difficulty with sex while also reducing the risk of their baby dying or getting cerebral palsy.

On the other hand, the college says it may slightly increase the risk of death for mothers while also increasing their risk of placenta accreta in future pregnancies – a serious complication that can cause significant blood loss. The recovery time is also longer compared with a vaginal delivery.

President of the college, Dr Rupert Sherwood, encouraged women to take part in the study.

Sourced & published by Henry Sapiecha

MILLION DOLLARS USA ABORTION DOCTOR

Thursday, January 20th, 2011

‘Kermit the killer’:

doctor stands accused of

eight murders in

‘house of horrors’

January 20, 2011 – 4:35PM
The "house of horrors"... The Women's Medical Society in Philadelphia, where Dr Kermit Gosnell allegedly made millions from abortions.The “house of horrors”… The Women’s Medical Society in Philadelphia, where Dr Kermit Gosnell allegedly made millions from abortions. Photo: AP

A US doctor, who gave abortions to minorities, immigrants and poor women in a “house of horrors” clinic, has been charged with eight counts of murder over the deaths of a patient and seven babies who were born alive and then killed with scissors, prosecutors say.

Dr Kermit Gosnell, 69, made millions of dollars over 30 years, performing as many illegal, late-term abortions as he could, prosecutors said.

State regulators ignored complaints about him and failed to inspect his clinic since 1993, but no charges were warranted against them given time limits and existing law, District Attorney Seth Williams said. 

Nine of Gosnell’s employees were also charged.

Gosnell “induced labour, forced the live birth of viable babies in the sixth, seventh, eighth month of pregnancy and then killed those babies by cutting into the back of the neck with scissors and severing their spinal cord”, Williams said.

Patients were subjected to squalid and barbaric conditions at Gosnell’s Women’s Medical Society, where Gosnell performed dozens of abortions a day, prosecutors said. He mostly worked overnight hours after his untrained staff administered drugs to induce labour during the day, they said.

Early last year, authorities went to investigate drug-related complaints at the clinic and stumbled on what Williams called a “house of horrors”.

Bags and bottles holding aborted foetuses “were scattered throughout the building,” Williams said. “There were jars, lining shelves, with severed feet that he kept for no medical purpose.”

The clinic was shut down and Gosnell’s medical licence was suspended after the raid.

Gosnell and four workers were charged with murder, while five others were charged with controlled drug violations and other crimes. None of the employees had any medical training, and one, a high school student, performed intravenous anaesthesia with potentially lethal narcotics, Williams said.

All 10 defendants were taken into custody, authorities said.

Two listed numbers for Gosnell in Philadelphia have been disconnected. Defence lawyer William J. Brennan, who represented Gosnell during the investigation, noted that the doctor served patients in a low-income city neighbourhood for decades.

“Obviously, these allegations are very, very serious,” Brennan said.

The grand jury said the woman who died was a patient who came to Gosnell’s clinic for an abortion and died of cardiac arrest because she was given too much Demerol. Gosnell wasn’t at the clinic at the time, but directed his staff to administer the drug to keep the woman, a healthy 41-year-old, sedated until he arrived, prosecutors said.

Gosnell has been named in at least 46 malpractice suits, including one over the death of a 22-year-old mother who died of sepsis and a perforated uterus in 2000. Many others also involve perforated uteruses. Gosnell sometimes sewed up the injury without telling women their uteruses had been perforated, prosecutors said.

Gosnell charged $325 for first-trimester abortions and $1600 to $3000 for abortions up to 30 weeks. Abortions are legal up to 24 weeks gestation in Pennsylvania, although most doctors won’t perform them after 20 weeks, prosecutors said.

Some women came from across the mid-Atlantic for the illegal late-term abortions, authorities said. White women from the suburbs were ushered into a separate, slightly cleaner area because Gosnell believed they were more likely to file complaints, Williams said.

“People knew near and far that if you needed a late-term abortion you could go see Dr Gosnell,” Williams said.

Few if any of the sedated women knew their babies were born alive and then killed, prosecutors said. Many were first-time mothers who were told they were 24 weeks pregnant, even if they were further along, authorities said.

Gosnell got his medical degree from Thomas Jefferson University in Philadelphia and is board certified in family practice. He started, but did not finish, a residency in obstetrics-gynaecologic, authorities said.

“He does not know how to do an abortion. He’s not board certified,” Assistant District Attorney Joanne Pescatore said. “Once he got them there, he saw dollar signs and did abortions that other people wouldn’t do.”

Sourced & published by Henry Sapiecha