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The Tree of Life plant Moringa Oleifera Kills 97% of Pancreatic Cancer Cells in Vitro

Thursday, June 15th, 2017

We just discovered an amazing report about Moringa, courtesy of our friends over at The Eden Prescription. In 2013 scientists reported in a paper published in BMC Complementary and Alternative Medicine (A peer-reviewed, open access journal) that A hot-water extract of the leaves of Moringa Oleifera killed up to 97% of human pancreatic cancer cells (Panc-1) after 72 hours in lab tests. Moringa leaf extract inhibited the growth of all pancreatic cell lines tested. [1]

Pancreatic cancer is very serious, one of the worst. Fewer than 6% patients with adenocarcinoma of the pancreas live five years after diagnosis. The typical treatment is currently chemotherapy.

Called the “miracle tree” on account of its many virtues, Moringa is very well known in India, parts of Africa, the Philippines and several other countries, yet it is relatively unknown in countries such as the USA. However it seems from the current buzz around it that it may well soon experience a rise to new popularity. It has a long history of use in traditional medicine due to its properties as an anti-fungal, anti-bacterial, antidepressant, anti-diabetes, pain and fever reducer and even asthma treatment. We’ve dedicated a full page on our site to a detailed herbal report on the amazing Moringa and those interested in herbalism would do well to investigate this plant.

It also contains numerous powerful anti-cancer compounds such as kaempferol, rhamnetin and isoquercetin. Now, researchers are discovering that Moringa has anti-cancer potential with positive results so far against ovarian cancer, liver cancer, lung cancer, and melanoma in lab tests. A list of these studies can be seen on Pubmed here.

Please note that it’s a long way before Moringa can be claimed as a cancer cure, but this kind of study is important because it indicates the potential for a starting point for a medicine of the future. It’s especially interesting because Moringa is already in common use – not only in herbalism but in a wide variety of other applications.

Moringa is now extensively cultivated throughout Asia, Africa, the Caribbean and Central America, but the largest Moringa crop in the world is produced by India – where it grows natively. It’s fascinating to note that may be one reason why the death rate from pancreatic cancer in India is a stunning 84% lower than in the United States!

**Moringa plants,material & seeds are available HERE.

Note – This article is not medical advice nor a substitute for consultation with a medical professional.

Note 2 – “In Vitro” literally means “In Glassware” and is the Latin expression to denote that the tests were done on cell cultures in a lab, as opposed to “In Vivo” which means tested on living creatures. Such studies indicate preliminary success but much more research will be needed to “prove” efficacy in humans. Though the huge disparity in pancreatic cancer rates in India is highly encouraging.

Check out our full “herbal page” on Moringa – tons of detailed information for those wishing to study this plant in depth: http://www.herbs-info.com/moringa.html

Please check out The Eden Prescription for more reports on the cutting edge science being done investigating the medicinal properties of herbs!

References:

[1] http://www.ncbi.nlm.nih.gov/pubmed/23957955

Moringa oleifera and the hot water infusions derived from its flowers, roots, leaves, seeds, and bark were also determined to possess antispasmodic, diuretic, and anti-inflammatory activities. In particular, the seed infusion appears to suppress the contraction induced by acetylcholine in this study (ED50 of 65.6 mg/mL) and the edema stimulated by carrageenan at 1000 mg/kg. Diuretic activity was noted at a concentration of 1000 mg/kg. Some of these cited biological properties were also noted in the roots. [24]

Moringa – Active Compounds

One thing that Moringa truly and clearly has under its belt is its being a rich and good source – not to mention affordable and readily accessible – of vital minerals and vitamins, protein, β-carotene, amino acids, and various phenolics. Zeatin, quercetin, β-sitosterol, caffeoylquinic acid, and kaempferol can also be isolated from Moringa. [25] Upon a comprehensive analysis of Moringa glucosinolates and phenolics (including flavonoids, anthocyanins, proanthocyanidins, and cinnamates), Bennett et al. (2003) found that:

The seeds contain 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate at high concentrations.

The roots have high concentrations of 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate and benzyl glucosinolate.

The leaves contain 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate and three monoacetyl isomers of this glucosinolate; quercetin-3-O-glucoside and quercetin-3-O-(6′ ‘-malonyl-glucoside); kaempferol-3-O-glucoside and kaempferol-3-O-(6’ ‘-malonyl-glucoside) in lower amounts; and 3-caffeoylquinic acid and 5-caffeoylquinic acid.

The bark contains 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate. [24]

Names of Moringa, past and present

English: Moringa, Horseradish Tree, Tree Of Life, Moringa Tree of Paradise, Moringa the Never Die Tree, Drumstick Tree, Ben Oil Tree, Ben Tree
Latin (scientific nomenclature): Moringa oleifera, Moringa pterygosperma, Hyperanthera moringa (archaic)
Tamil: Murungai / Murungai Maram
Mandarin: la mu
Cantonese: lat mok (lit. ‘spicy wood’)
Filipino: malunggay / kamungay
Hindi / Indian: munaga / shajna
Spanish: palo de aceite / libertad
French: ben olifiere
Ayurvedic: Shigru / Shobhanjana
Hindi: Sahjan
Punjabi: Surajan
Konkani: Mhasanga Saang
Telugu: Munagachettu

Morniga – General Information

Moringa is a genus of 13 species of tropical and subtropical plants. The most widely known of these, and the subject of this article, is Moringa oleifera – a tree native to northwestern India. Moringa oleifera, commonly referred to as just “Moringa”, grows fast in a variety of climates and is cultivated in many regions because it can grow in poor or even some barren soils. Much of the plant is edible. The leaves are nutritious and are used as food for people and feed for livestock. [1]

The moringa tree is often referred to by its advocates as the ‘tree of life’ due to its seemingly miraculous nutritional benefits and sheer versatility. This unassuming, curiously shaped tree is grown as a landscape tree and food source in many parts of the world – although its use as a type of vegetable and nutritive food first developed in countries such as Africa, the Himalayas, China, Malaysia, Thailand, and the Philippines. This hardy plant grows in a wide variety of soils ranging from sandy, loamy, and even clayish soils and is resistant to drought and is fast-growing. Due to its hardiness, moringa can be found growing in different climates, and with its adaptability (with the exception that it does not tolerate frost very well), the trees are easily grown and cultivated with very little to no maintenance required. [2]

The moringa tree, when left to its own devices, usually grows as much as ten metres, although when cultivated for its leaves, seed pods (aka ‘drumsticks’), seeds, or flowers it is usually trimmed and maintained at an easily reachable length of one to three metres tall to allow for easier harvesting of its constituent parts.

Proponents of Moringa oleifera sing its praises. It has been described as “one of the most useful plants that exists” – owing to its unusual combination of high nutritional value, medicinal properties, fast growing and ability to thrive in arid environments. The leaves are rich in vitamins, proteins and minerals such as calcium, potassium and iron.

One of the reasons the Moringa tree can thrive in arid regions is that it has a long taproot – which also makes it valuable against soil erosion. [3] The main products made from the plant are edible seed oil, tea leaves and animal feed. The seed kernels are also used by the French perfume manufacturing industry. [4] The Moringa tree is now widely cultivated in Africa, Sri Lanka, India, Central and South America, Malaysia, Indonesia and the Philippines. The tree is in full leaf at the end of the dry season when other food may be scarce. [5]

Moringa oleifera is listed in the AHPA’s “Herbs of Commerce”, p98. [6]

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References & Further Reading

[1] http://en.wikipedia.org/wiki/Moringa

[2] http://en.wikipedia.org/wiki/Moringa_oleifera

[3] http://www.miracletrees.org

[4] http://web.archive.org/web/20090906184503/http://www.shaebia.org/artman/publish/article_5934.shtml

[5] http://en.wikipedia.org/wiki/Moringa_oleifera

[6] “Herbs of Commerce” (AHPA) (2000 edition) – Michael McGuffin, John T. Kartesz, Albert Y Leung, Arthur O. Tucker p.98

[7] http://www.plantnames.unimelb.edu.au/Sorting/Moringa.html

[8] http://books.google.com/books?id=ZUw-AAAAcAAJ

[9] http://www.treesforlife.org/our-work/our-initiatives/moringa

[10] http://web.archive.org/web/20120821200349/http://moringafact.com/health-benefit-of-moringa-leaves-and-moringa-seeds/

[11] http://edlagman.com/moringa/moringa-health-benefits.htm

[12] http://leafpower.wordpress.com/moringa-benefits/

[13] http://www.mb.com.ph/articles/201276/moringa-malunggay-philippines#.ULEkU-Tqk8o

[14] http://www.sooperarticles.com/food-drinks-articles/health-benefits-recipe-ben-oil-tree-malunggay-798017.html

[15] http://www.moringasource.com/moringa-oil.php

[16] http://www.moringasource.com/moringa-benefits.php

[17] http://www.ngrguardiannews.com/index.php?option=com_content&view=article&id=95883:the-nutritional-and-healing-benefits-of-moringa&catid=105: saturday-magazine&Itemid=566

[18] http://books.google.com/books?id=tR6gAAAAMAAJ (p.123)

[19] http://www.ncbi.nlm.nih.gov/pubmed/19666102

[20] Anwar F., Latif S., Ashraf M., & Gilani A. H. (2007). Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy Research, 21(1): 17–25. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pubmed/17089328/

[21] Mbikay M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Frontiers in Pharmacology, 3:24. doi: 10.3389/fphar.2012.00024. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290775/

[22] Ndong M., Uehara M., Katsumata S., & Suzuki K. (2007). Effects of oral administration of Moringa oleifera Lam on glucose tolerance in Goto-Kakizaki and Wistar rats. Journal of Clinical Biochemistry and Nutrition, 40(3): 229–233. doi: 10.3164/jcbn.40.229. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pubmed/18398501/

[23] Jaiswal D., Kumar Rai P., Kumar A., Mehta S., & Watal G. (2009).Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. Journal of Ethnopharmacology, 123(3): 392–396. doi: 10.1016/j.jep.2009.03.036. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pubmed/19501271/

[24] Cáceres A., Saravia A., Rizzo S., Zabala L., De Leon E., & Nave F. (1992).Pharmacologic properties of Moringa oleifera. 2: Screening for antispasmodic, antiinflammatory and diuretic activity. Journal of Ethnopharmacology, 36(3): 233–237. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pubmed/1434682/

[25] Bennett R. N. et al. (2003).Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. Journal of Agricultural and Food Chemistry, 51(12): 3546–3553. Retrieved 23 March 2013 from http://www.ncbi.nlm.nih.gov/pubmed/12769522/

*** MORINGA PLANTS-SEEDS & MATERIAL AVAILABLE HERE

CONTENT FOR THIS ARTICLE WAS OBTAINED FROM THE GREAT SITE BELOW

http://www.herbs-info.com/moringa.html

Henry Sapiecha

Universal Cancer Vaccine Is Probably Impossible

Monday, February 27th, 2017

Cancer-Vaccine-image www.newcures (2)

The quest for vaccines to prevent cancers just hit a theoretical limit: If there ever are vaccines, there will have to be many, and not just one.

In theory, the best possible treatment for cancer would be one that required no radiation or surgery, instead using the body’s immune system to turn back a tumor’s uncontrollable growth. Recent developments in using immunotherapy to treat cancer has researchers thinking about a cancer vaccine as a potential breakthrough in prevention. But new research suggests that we shouldn’t hold out much hope for a single, universal vaccine for cancer.

While the first scientist to look at the immune system’s potential role in treating cancer conducted his research in the 1890s, it’s only in the past decade that immunotherapy has really taken off. Most famously, President Jimmy Carter was declared cancer-free in 2016 after immunotherapy was used to help treat a brain tumor. The basic principle is the same as any other disease the immune system deals with. The body’s defense mechanisms recognize the tumor as an invader and attack it, neutralizing the threat. The challenge lies in getting the immune system to see the tumor as a harmful, unwanted presence. It’s possible to do that by training the body’s immune system to recognize certain molecules in the tumor’s makeup.

A cancer vaccine would be the next big step for immunotherapy. While there are vaccines for cancers that are caused by an underlying infection — the HPV vaccine is probably the best-known example — vaccines meant to target non-infectious tumors are trickier. Some are in clinical trials to deal with specific types of cancer, but none are yet approved in the United States.

Based on researchers’ current knowledge, a cancer vaccine would require focusing on specific genetic alterations in tumors, which create molecules that the immune system can then target and attack if a tumor ever does pop up. The problem is that those alterations are different in every person, so each vaccine would have to be specifically designed and created for every individual patient. That would be expensive, likely prohibitively so.

The bad news, according to scientists at the cancer genetics research company Foundation Medicine and authors of the study, is that there doesn’t appear to be any way around that problem that would allow for the creation of a universal vaccine. They looked at the genomes of more than 60,000 different tumors to find any molecules that were the consistent result of these genetic alterations and that the immune systems could then go after. Even in the best-case scenario, the most common targets the researchers found would only be useful for about 0.3 percent of the population.

So a universal vaccine doesn’t appear to be possible, at least based on what we know right now. The researchers did point out that they only looked at the specifically cancer-causing parts of the tumor genomes, and it’s possible a currently unknown genetic alteration could be common enough to make a universal vaccine more feasible.

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Henry Sapiecha

Scientists develop system to stop cancer cells before they go further

Friday, April 1st, 2016

New biosensor mouse helps researchers stop cancer in its tracks before it spreads to other organs.

live_imaging_of_breast_cancer_image www.newcures.info

A large team of scientists from Australia and the UK have created a “biosensor mouse” in which they can track pancreatic cancer cells in real time with the help of fluorescence.

Using this new biosensor technique, the researchers even managed to prevent aggressive pancreatic cancer cells from spreading in a live mouse. In time, this biosensor tool could lead to better testing of new, promising cancer drugs.

“Our biosensor mouse makes it possible to look at a primary tumour that has not yet spread – in real time, in 3D and in a living tumour,“ said Dr Paul Timpson from Sydney’s Garvan Institute of Medical Research, who co-led the study with Prof Kurt Anderson of the Beatson Institute for Cancer Research (UK).

To create the biosensor mouse, researchers attached a green fluorescent protein from jellyfish to a molecule called E-cadherin – a protein involved in holding cells together. When this molecule stops working properly, cancer cells can become invasive.

“In pancreatic cancer, before it spreads, this molecule must “unzip”, the cells must stop touching each other so they’re not held together, and then they start invading the body,” said Timpson. Once these tumour cells settle in other organs, it becomes a metastasis – and most types of metastatic cancer currently can’t be treated.

Once the protein “zipper” molecule was made glow-in-the-dark, researchers could use a laser to determine how tightly the cells were holding together. They could watch in real time as the tumour cells started to lose the protein zipper holding them in place – catching the moment before cancer would set off on an invasive spread.

Stopping the cancer in its tracks

Pancreatic cancer doesn’t have a routine screening test, and is often diagnosed at late stages, when the tumour cells have already spread to other organs. According to Garvan Institute, each year roughly 2500 Australians are diagnosed with pancreatic cancer – and nearly 95 percent of them die within five years. If cancer is caught early and stopped before it spreads, the chance of survival becomes much higher.

To give cancer to the biosensor mouse, researchers introduced two genetic mutations responsible for creating most pancreatic cancers in humans – particularly one type that’s known to be invasive.

“What amazed us was that we could actually stop the spread of disease, keeping it local and stopping it in its tracks,” Timpson told SBS.

When they saw cancer cells starting to unzip, the researchers treated the mice with anti-invasive cancer drugs, dasatinib and saracatinib. “Within three days of treatment, we saw cells within the tumour had rezippered, and we could stabilise the primary tumour,” said Timpson.

“We’re now looking to see if we can use this beyond pancreatic cancer, and start in breast cancer, and colon cancers, for example.”

Promise of new cancer treatment

“We’ve actually already started discussions with large pharmaceutical companies both in Europe and Australia,” Timpson explained. For companies with various anti-cancer drugs in the development pipeline, this new biosensor mouse will become a valuable tool to better test whether a particular medication might be able to stop the disease from spreading.

Testing usually starts out in a petri dish, but this doesn’t always give a clear indication of whether the drug works, because cells can respond differently when they’re taken out of the body.

Professor Alpha Yap from the University of Queensland’s Institute for Molecular Bioscience has praised the research, calling it valuable.

“For the first time we are able to test how the E-cadherin adhesions between cancer cells respond to drugs when the cancers remain within the body,” said Yap, who wasn’t involved in the study. “This is an important contribution in the search to understand cancer and develop new treatments for it.”

Unfortunately, this approach can’t be used for cancer that’s already spread – but Timpson says the team is working on additional models. “We’re also creating other mice to look at different stages of cancer, so I would say it’s a major breakthrough in terms of tools for discovering new cancer drugs.”

The study was published today in Cell Reports.

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HenrySapiecha

 

Skin cells turned into brain tumor & cancer predators

Friday, February 26th, 2016

skin-cancer-tumor-killer-image www.newcures.info

Reprogrammed stem cells (green) chase down and kill glioblastoma cells (pink) (Credit: UNC Eshelman School of Pharmacy)

The 2006 discovery that mature skin cells can be converted into stem cells opened up exciting possibilities in regenerative medicine. Now almost a decade later, the Nobel-Prize winning research of Shinya Yamanaka is still opening doors for scientists across different arms of medical research. In what it labels as a first, a team from the University of North Carolina at Chapel Hill (UNC) has built on this technology to transform adult skin cells into cancer-killing stem cells that seek and destroy brain tumors.

Glioblastomas are the most common and fatal form of brain cancer, carrying a survival rate beyond two years of just 30 percent. While surgeons can remove the tumor, often its cancerous tentacles take root deep in the brain and allow it to grow back. Most patients die within a year and a half of diagnosis.

Radiation and chemotherapy can be used to tackle tumors that cannot be surgically removed, but the UNC research team is working towards yet another treatment that zeroes in on these tentacles as a means of further boosting survival rates.

The team harvested adult skin cells called fibroblasts, which produce collagen and connective tissue, and engineered these to become induced neural stems cells. They then administered these cells to mice, observing that they had the ability to go hunting through the brain for remaining cancer cells and kill them off.

This led to an increase in survival times ranging from 160 to 220 percent, depending on the type of tumor. The team says it is also possible to engineer the stem cells to produce a tumor-killing protein, which would make them an even more potent weapon against cancer.

The team mixed stem cells into an FDA-approved surgical glue, which provided a physical matrix to support them while they sought out the cancerous tentacles. The team is now exploring ways to further improve this staying power, along with the potential to load anti-cancer drugs into the stem cells.

“Our work represents the newest evolution of the stem-cell technology that won the Nobel Prize in 2012,” says Shawn Hingtgen, an assistant professor at UNC. “We wanted to find out if these induced neural stem cells would home in on cancer cells and whether they could be used to deliver a therapeutic agent. This is the first time this direct reprogramming technology has been used to treat cancer.”

The research was published in the journal Nature Communications.

Source: University of North Carolina at Chapel Hill

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Henry Sapiecha