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Australian not-for-profit group wins unprecedented FDA approval for blindness drug

Sunday, July 22nd, 2018

London: An Australian company has won unprecedented US approval for a new drug to treat the second most common preventable cause of blindness in the world.

In the process, Medicines Development for Global Health, based in Melbourne, became the first not-for-profit company in the world to register a medicine with the US Food and Drug Administration.

Mark Sullivan, managing director of Medicines Development for Global Health.

Photo: Supplied

The World Health Organisation has been calling for better treatments for river blindness for more than a decade, but because the medicine would be mostly used by those in poverty-stricken countries, there has been no financial incentive for drug companies to develop new treatments. The current treatment is 20 years old.

River blindness is caused by parasitic worms and spread by black flies. It affects the skin and eyes and is prevalent in sub-Saharan Africa.

In a double-win for Medicines Development for Global Health, it has also won a highly sought after voucher designed to financially reward companies that develop drugs for neglected diseases.

Managing director Mark Sullivan said while FDA approval for the company’s drug, moxidectin, was a “momentous achievement” for any pharma company, it was “a particularly rare and exciting event” for those trying to treat neglected diseases.

The FDA gave its approval for the treatment, which is swallowed as a tablet, in June after the application was submitted in October 2017.

Mr Sullivan established the Melbourne-based not-for-profit company in 2005 with the sole purpose of filling the gap left by the big pharmaceutical companies by developing medicines that were based on need for treatment rather than the patients’ ability to afford them.

Medicines Development for Global Health has been working for five years on the development of the drug and is now planning to develop moxidectin as a new treatment for scabies, a common problem in Indigenous communities.

Priority review voucher

The company has also won a priority review voucher under a scheme set up in 2007 to create a financial incentive to reward drug makers willing to spend the time and money developing treatments for the some of the world’s most neglected diseases. The scheme creates a market for making new drugs that the private market was not filling itself.

Under the scheme, a company that wins a voucher gets a fast track through the FDA for consideration of its  next new drug,  even if it’s a treatment that would have a commercial return. This gives it a head-start over its rivals.

Crucially, a company can also on-sell the voucher to a bigger company willing to pay anywhere between $US100 million and $300 million for the right to almost halve the approval time.

Because Medicines Development for Global Health is a not-for-profit, its proceeds from drug sales and the voucher will be reinvested in the company to develop new drugs & medications for other neglected diseases.

“Our plan is to sell the voucher and use the funds to support further development of moxidectin for other neglected diseases but also to expand our portfolio into other medicines and vaccines,” Mr Sullivan said.

Professor David Ridely from Duke University authored the scheme and said Medicines Development for Global Health was a textbook example of how he envisaged the program would work.

“I’m delighted that the voucher program is playing a role in treating patients with river blindness, and one day eliminating the disease,” he said.

Mr Sullivan said the development of moxidectin could not have been possible without a $US13 million co-investment from the Global Health Investment Fund, which is the social impact investment fund initially put together by the Bill and Melinda Gates Foundation.

”We believe moxidectin may play a pivotal role in eventually eradicating river blindness, and look forward to working with MDGH and others in making this happen,” Curt LaBelle, managing partner at the investment fund, said.

Color-enhanced Scanning Electron Micrograph (SEM) of Onchocerca volvulus, image of a female worm with microfilaria. O. volvulus is a nematode that causes onchocerciasis, or “river blindness,” mostly in Africa. Long-term corneal inflammation, or keratitis, leads to thickening of the corneal stroma which ultimately leads to blindness.

The Food and Drug Administration (FDA) has approved moxidectin for the treatment of onchocerciasis (river blindness) due to Onchocerca volvulus in patients ≥12 years of age.

Moxidectin, a macrocyclic lactone, is an anthelmintic drug that selectively binds to the parasite’s glutamate-gated chloride ion channels. It is active against O. volvulus microfilariae but it does not kill adult O. volvulus parasites. The tropical disease spreads from person to person via black flies that breed near rivers in South and Central America, sub-Saharan Africa and Yemen

RELATED LINKS
 1 in 2 men and 1 in 3 women will develop cancer in their lifetimes. This saddening reality is made worse when it is acknowledged that modern methods of ‘treating’ the disease are often ineffective and only make the symptoms of the disease far worse. In fact, according to one Berkeley doctor, Dr. Hardin B. Jones, chemotherapy doesn’t work 97% of the time.

In the eye-opening video above, Dr. Hardin B. Jones, a former professor of medical physics and physiology at the University of California, Berkeley, discusses how ‘leading edge’ cancer treatment is a sham.

Studied life expectancy of patients for over 25 years

He has personally studied the life expectancy of patients for more than 25 years and has come to the conclusion that chemotherapy does more harm than good. The bone-chilling realization prompted Dr. Jones to speak out against the billion-dollar cancer industry.

“People who refused chemotherapy treatment live on average 12 and a half years longer than people who are undergoing chemotherapy,” said Dr. Jones of his study, which was published in the New York Academy of Science.

“People who accepted chemotherapy die within three years of diagnosis, a large number dies immediately after a few weeks.” 

According to the physician, the only reason doctors prescribe chemotherapy is because they make money from it. Such an accusation doesn’t seem unreasonable, as cancer

Patients rejecting conventional therapy live 4x longer

“Patients with breast cancer who reject conventional therapy live four times longer than those who follow the system. So this is something that you will not hear in the mass media, which will continue  the myth…”

Despite the fact that the United States spends more on healthcare than any other high-income nation in the world, diseases of affluence continue to increase in prevalence, resulting in a shorter life expectancy.

Perhaps this is because mainstream media and the allopathic healthcare system don’t teach about the importance of preventative medicine. Eating a healthy diet, engaging in exercise, thinking positive thoughts, reducing stress, and enjoying the company of others – or habits that bring joy – are all proven to improve longevity and happiness.

Natural alternatives

In addition, potent all natural medicines, such as cannabis oil, are also strictly regulated and illegal in many areas – despite the fact that CBD-rich oil from the marijuana plant is listed as a remedy on the U.S.’ National Cancer Institute’s website.   www.druglinks.info

As it is, there is no money in a healthy population, which is why fast food joints and pharmaceutical industries thrive in America. Hopefully, Dr. Jones’ efforts will inspire people to seek out alternative options if they or someone they know develops the debilitating disease.

RELATED LINKS BELOW

www.druglinks.info

www.sunblestproducts.com

www.pythonjungle.com

www.ozrural.com.au

Henry Sapiecha

CAESALPINIA PULCHERRIMA L. – PRIDE OF BARBADOS. TRADITIONAL MEDICINAL PLANT OF THE SURINAMES

Tuesday, July 10th, 2018

CAESALPINIA PULCHERRIMA L. – PRIDE OF BARBADOS

Caesalpinia Pulcherrima Synonym Poinciana pulcherrima, Poinciana bijuga.
Common name Pride of Barbados, dwarf poinciana, red bird of paradise, krere – krere, Barbados flower – fence, pearock flower, tabachin, tabaquin.
Family Caesalpinaceae and Fabaceae.

Overview

Pride of Barbados is a small evergreen perennial shrub or tree, from the West Indies, 10 – 15 feet high with alternate, bipinnate leaves. The stem and branches are armed with spines. The red, orange, yellow and pink flowers grow at the end of the prickly branches. This small, graceful tree flowers throughout the year and is a beautiful garden plant. Pride of Barbados has beautiful bowl – shaped flowers in the colors red, orange, orange – red and yellow. The yellow variety is often called yellow bird of paradise.

The fruits are legumes, 3 – 4″ long; when ripe they split open and release the brown bean. The variety of pride of Barbados with red flowers is also called red bird of paradise, while the yellow species is called phoenix bird of paradise. Closely related is the Yellow bird of paradise (Caesalpinnia gilliesii) which has yellow flowers with long red stamens.

*** Suriname’s traditional medicine The leaves are purgative and used against kidney stones, malarial fever and bronchitis.

**** Flavonoids isolated from this plant possess anti-inflammatory activities; the flavonoid of quercetin has antiviral activity. Pride of Barbados exhibit a broad spectrum of antimicrobial activity, particularly against Escherichia coli (enteropathogen), Proteus vulgaris, Pseudomonas aeruginosa and Staphylococcus aureus.

**** The root and stem seem to be cytotoxic.(damages or destroys cancerous cells).

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SEEDS OF THIS PLANT ARE AVAILABLE TO PURCHASE

MORE ON THIS PLANT >>HERE

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Henry Sapiecha

Scientists Find Substance In Mangosteen Kills 99% Of Breast & other Cancer Cells In lab tests

Tuesday, July 3rd, 2018

This is a follow up on an earlier posting on Mangosteen in this site.

Great news for mangosteen lovers and those following the quest to find novel anti-cancer medicines derived from plants! We just received this report from our friends over at The Eden Prescription: In a new study published in Molecular Cancer (an open-access, peer-reviewed journal) alpha-mangostin, a substance derived from mangosteen pericarp, was shown to kill up to 99% of human breast cancer cells in vitro.*

What was particularly interesting about this study was that the researchers gained a deeper understanding of the mechanism of action of the mangosteen-derived substance. Alpha-mangostin was reported to block Fatty Acid Synthase – which disrupts the cancer cells’ ability to make fatty acids – without which they die. [1]

It appears that numerous cancer cell types require Fatty Acid Synthase for their survival, which may be the reason why mangostin has received much attention recently; it has also been found deadly also to prostate, liver, colon, and pancreatic cancers as well as leukemia.

Mangosteen (Garcinia mangostana) is an amazing, delicious tropical fruit – one of my favorites in fact – and was originally native to Thailand. Don’t be fooled by the name, it does not look or taste like a mango. Mangosteen has a thick, pithy casing (pericarp) which is easily broken or cut open to reveal the white, fleshy part inside that is eaten. Mangosteen is also considered potentially valuable with weight loss, inflammation, heart disease and diabetes! However it is the pericarp that may have the strongest medicinal qualities. For centuries, people in Southeast Asia have used dried mangosteen pericarp as antiseptic, anti-inflammatory, anti-parasitic, antipyretic, analgesic, and as a treatment for rashes. [2]

Tests like the study mentioned are the first step in the development and study of new medicines. It’s a long way before we can say for certain that mangosteen will have a direct anti-cancer action in humans – and in this study the beneficial substance was in the pericarp (the pithy case). However there have now been several promising studies on mangosteen extracts – including a 2013 study in which alpha-mangostin significantly suppressed tumor growth and reduced lymph node metastasis in mammary cancer in mice; leading researchers to conclude that “Mangosteen extracts appear to, in fact, have chemopreventive qualities and might prove useful as adjunctive and/or complementary alternative treatments in human breast cancer.” [2]

Mangosteen pericarp is available in supplement form.

* “In vitro” (literally “in glass”) is a scientific term used to denote that the test was done on isolated cell cultures in laboratory glassware, as opposed to in living creatures (“In vivo”).

www.sunblestproducts.com

Henry Sapiecha

THIS 11YR OLD GIRL HAD HUGE TUMOUR OF 10 KILOS GROWING INSIDE OF HER

Tuesday, May 22nd, 2018

A Queensland Australia schoolgirl had a mass growing so big inside her doctors thought she might have been pregnant.When little Cherish-Rose Lavelle started quickly losing weight her mother Louise knew something was amiss.

After taking the the 11-year-old for a medical examination, it wasn’t long before she was transferred to hospital in Hervey Bay and sent directly to the capital of Brisbane by plane.The aggressive germ-cell cancer was causing Cherish-Rove a lot of pain and Ms Lavelle noticed her daughter’s normally bubbly personality was very different over two months.Rare for a girl of Cherish-Rose’s age, the cancer will set her back a bit from starting Year 6 this month.’This morning she was bright and smiling but right now she is very dispondent,’ Ms Lavelle told the Daily Mail Australia.

Now Ms Lavelle must sell her op-shop business so she can spend months looking after her daughter in hospital.’It’s going to be a long haul,’ she said.Ms Lavelle initially thought her daughter was suffering an eating disorder before she discovered something more sinister was at play.’This is something I want parents to be aware of as I thought she was suffering an eating disorder from being bullied for being overweight,’ she said.’She suddenly lost 14-15kg and I started to demand food into her because I was frightened and then when the pain started in her belly and back I was clueless.’When I was told she had cancer I couldn’t stop crying, it broke my heart.’Now I’ve been told that it is curable I am so very relieved.Now my life has changed nothing else is of importance at all.’ Chemo will shrink the tumour quickly so Cherish-Rose can go into surgery to have it removed.It is another blow for Ms Lavelle who discovered the manager in her shop was allegedly abusing her role through fraud, having to let her and others go and leaving her short staffed as this stressful time.Heartfelt messages have been shared on social media wishing the inspirational young girl all the best with her health & her future..

www.goodgirlsgo.com

www.ozrural.com.au

Henry Sapiecha

Young boy has his seizures cured with cannabis oil-The family story here.

Monday, February 19th, 2018

This is Sam. He’s my son. His epilepsy caused him to have up to 100 seizures a day. After seven years we were out of options. Our last hope: an untested, unproven treatment. The only problem? It was illegal.

www.druglinks.info

The hospital pharmacist slid three bottles of pills across the counter, gave my wife a form to sign, and reminded her that this was not the corner drugstore. The pharmacy knew how many pills had been dispensed, he said; it would know how many had been consumed; and it would expect her to return the unused pills before she left the country. The pharmacist made it clear that he was not only in touch with our doctor but with the company supplying the medication. They would know if she broke the rules. MORE

There are products here below that may help you

Henry Sapiecha

www.druglinks.info

THIS WOMAN SAYS SHE CURED HER CERVICAL CANCER WITH CANNABIS OIL

Sunday, February 4th, 2018

 

Shona Leigh said she had second stage cervical cancer cured in eight months using oil supplied freely.

MORE HERE

Henry Sapiecha

 

 

The Tropical Fruit Mangosteen has been found deadly to prostate, liver, colon, and pancreatic cancers as well as leukemia.

Sunday, January 21st, 2018

Great news for mangosteen lovers and those following the quest to find novel anti-cancer medicines derived from plants! We just received this report from our friends over at The Eden Prescription: In a new study published in Molecular Cancer (an open-access, peer-reviewed journal) alpha-mangostin, a substance derived from mangosteen pericarp, was proven to kill up to 99% of human breast cancer cells in vitro.*

What was particularly interesting about this study was that the researchers gained a deeper understanding of the mechanism of action of the mangosteen-derived substance. Alpha-mangostin was reported to block Fatty Acid Synthase – which supposedly disrupts the cancer cells’ ability to make fatty acids – without which they die.

It appears that numerous cancer cell types require Fatty Acid Synthase for their survival, which may be the reason why mangostin has received much attention recently; it has also been found deadly also to prostate, liver, colon, and pancreatic cancers as well as leukemia.

Mangosteen (Garcinia mangostana) is an amazing, delicious tropical fruit – one of my favorites in fact – and was originally native to Thailand. Don’t be fooled by the name, it does not look or taste like a mango. Mangosteen has a thick, pithy casing (pericarp) which is easily broken or cut open to reveal the white, fleshy part inside that is eaten. Mangosteen is also considered potentially valuable with weight loss, inflammation, heart disease and diabetes! However it is the pericarp that may have the strongest medicinal qualities. For centuries, people in Southeast Asia have used dried mangosteen pericarp as antiseptic, anti-inflammatory, anti-parasitic, antipyretic, analgesic, and as a treatment for rashes. [2]

Tests like the study mentioned are the first step in the development and study of new medicines. It’s a long way before we can say for certain that mangosteen will have a direct anti-cancer action in humans – and in this study the beneficial substance was in the pericarp (the pithy case). However there have now been several promising studies on mangosteen extracts – including a 2013 study in which alpha-mangostin significantly suppressed tumor growth and reduced lymph node metastasis in mammary cancer in mice; leading researchers to conclude that “Mangosteen extracts appear to, in fact, have chemopreventive qualities and might prove useful as adjunctive and/or complementary alternative treatments in human breast cancer.” [2]

Mangosteen pericarp is available in supplement form.

* “In vitro” (literally “in glass”) is a scientific term used to denote that the test was done on isolated cell cultures in laboratory glassware, as opposed to in living creatures (“In vivo”).

www.foodpassions.net

Henry Sapiecha

Turmeric could Be The World’s Most Important Herb.600 reasons why.PLEASE SHARE.

Tuesday, November 14th, 2017

This article was supplied by herbs-info.com

We found a simply astonishing page all about Turmeric and had to share! I honestly think it is one of the best pages about a herb I have ever seen (and I’ve seen a fair number!) The link is after our commentary.

There are several things that are amazing about the page we discovered. First – of course – the fact that there is scientific research to support the notion that turmeric may be beneficial for a staggering 600+ conditions. It is one of the world’s most studied items for medicinal potential, with over 4000 scientific studies being recorded overall.

Then there is the fact that the mighty turmeric has been in use for over 6000 years, with an incredible safety record. Note also, the effects of turmeric have been found by scientists to be greatly enhanced when it is taken in combination with black pepper (see our report here – Substance In Black Pepper Increases Bioavailability Of Beneficial Turmeric Compounds by 2000% )

Even more amazing is the way the article weaves a crystal-clear narrative that exposes the farce behind the fact that the modern medical world will perhaps never approve turmeric “officially” for medical use. It explains clearly that “proof” is effectively only purchased by those with very deep pockets (802 million dollars on average is the cost for obtaining a new drug approval). [1] The situation is a complete joke. Turmeric is clearly and obviously one of the most benign and beneficial things in the known universe.

But most amazing of all, to me, was the comment from the man who states calmly that he is one of the world’s longest survivors of the kidney transplant operation (34 years since the op, the world record is 40 years) and he takes capsules of turmeric (and other herbs) daily. Truly inspiring stuff.

The original article is fantastic, electrifying even – and we encourage you to share this article www.newcures.info  far and wide. Here’s the link: http://www.greenmedinfo.com/blog/600-reasons-turmeric-may-be-worlds-most-important-herb

www.foodpassions.net

Henry Sapiecha

HUGE LIST OF HERBS USED FOR DISEASE TREATMENTS CURES & BENEFITS-SHARE

Tuesday, November 14th, 2017

This information has been supplied by herbs-info.com

List Of Herbs

On this page you will find our alphabetical list of 150+ 189 herbs! Every herb in our list has its own dedicated page on this site – with pictures and very detailed info! Follow the links to learn more about each herb. The goal of the individual herbs’ pages is to gather information about the plant in one place, so that anyone researching it can have quick access to information.

Please bookmark this page so that you can use it as a “quick lookup” when you want to learn all about a herb. You can also share our image on Facebook and Pinterest. Each herb page follows a similar format – starting with names for the herb in different languages, then giving background and history, common and traditional uses of the herb, scientific research, esoteric uses and safety notes.

Our method of organization intentionally follows the style of the old herbals, which listed the plants in alphabetical order and often compiled the writings of other herbalists from past times. There is much material to work through and so this list is continuing to expand. Ok, here is the list!

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The Herbs:There are many more to yet come.

Agrimony | Ajwain | Alfalfa | Alkanet | Allspice | Aloe Vera | Althaea Officinalis (Marsh Mallow) | Amla | Angelica | Angostura | Anise | Arabian Jasmine | Arnica | Arrach | Artemisia | Asafoetida | Ashwagandha | Bacopa Monnieri | Bashful Mimosa | Basil | Bay Laurel | Bean | Bears Breech | Belladonna | Benzoin | Bergamot | Betony | Bilberry | Bitter Melon | Black Pepper | Blackberry Bush | Blumea Camphor | Boneset | Borage | Brooklime | Bryony | Bugle | Burdock | Butterbur | Cacao | Cajeput | Calendula | Canella | Capers | Cardamom | Carob Tree | Cascara Sagrada | Cascarilla | Catechu | Catnip | Cat’s Whiskers | Catsfoot | Cayenne | Cedron | Celery | Centory | Chamomile | Cheken | Chervil | Chinese Honeysuckle | Chives | Cilantro | Cinnamon | Clavo Huasca | Clove | Coltsfoot | Comfrey | Contrayerba | Copal | Cordyceps | Cumin | Daffodil | Damiana | Dandelion | Deadly Nightshade | Dill | Dittany Of Crete | Dodder | Dragon’s Blood | Echinacea | Elder | Epazote | Female Peony | Fennel | Fenugreek | Feverfew | Five Leaved Chaste Tree | Flax | Frankincense | Galangal | Garlic | Gentian | Ginger | Gingko Biloba | Ginseng | Goat’s Rue | Goji | Golden Seal | Gotu Kola | Green Tea | Guarana | Guava | Hearts Ease | Heavenly Elixir | Hedge Nettle | Henna | Hibiscus | Hollyhocks | Holy Basil | Holy Basil | Honeysuckle | Hops | Horny Goat Weed | Horseradish | Horsetail | Hyacinth | Indian Laurel | Jew’s Mallow | Juniper | Kava | Ladies Mantle | Lady’s Thistle | Lavender | Lead Tree | Lemon Balm | Lemongrass | Lesser Calamint | Licorice | Lily of the Valley | Male Satyrion | Marjoram | Milk Thistle | Moringa | Mountain Apple | Mugwort | Mullein | Neem | Nelumbo Nucifera | Nutmeg | Nymphaea Caerulea | Onion | Oregano | Orris Root | Paprika | Parsley | Passion Flower | Patchouli | Pepper Elder | Pimiento Pepper | Plantain | Primrose | Queen’s Flower | Red Clover | Reishi | Rhubarb | Ringworm Bush | Rooibos | Rosemary | Rue | Saffron | Sage | Savory | Saw Palmetto | Seaweed | Senna | Slippery Elm | Snake Needle Grass | Snakeweed | Soapnuts | Solomon’s Seal | Spearmint | Spiny Sapindus | St. John’s Wort | St Thomas Bean | Star Anise | Starfruit | Stinging Nettle | Sumac | Sweetsop | Tamarind | Tarragon | Tea | Thyme | Turmeric | Uva-Ursi | Valerian | Vanilla | Vervain | Water Hyssop | Wild Oregano | Wild Tea | Witch Hazel | Yarrow | Yerba Mate |

www.foodpassions.net

Henry Sapiecha