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Archive for the ‘FERTILITY’ Category

Human sperm grown in lab for first time, say scientists

Monday, May 11th, 2015

Sperm created from embryonic stem cells at Newcastle University in Britain image www.newcures.info

Sperm created from embryonic stem cells at Newcastle University in Britain.

London: Human sperm cells have been grown in a laboratory for the first time, in a breakthrough that could lead to a treatment for male infertility, scientists claim.

A French firm said it had produced “fully formed” sperm from basic reproduction cells.

The research has not yet been published in a peer-reviewed journal, and experts greeted the news with caution. However, if proven, the technique could offer hope to people who cannot have children.

The Kallistem laboratory in Lyon said its finding paved the way for new methods of treating infertile men

“At the end of 2014, the company was able to produce fully formed human spermatozoa [sperm cells] in the laboratory setting, using patient testicular biopsies containing only immature germ cells, or spermatogonia,” the company said in a statement.

“This research paves the way for innovative therapies to preserve and restore male fertility, a major issue with global impact; numbers of spermatozoa have declined by 50 per cent over the last 50 years.”

Joyce Harper, professor of human genetics and embryology at University College London, said: “This is a great move forward – it is really exciting.”

However, she added: “They have said that this is still early stages and we’ve got a long way to go, and that is absolutely correct. There are a number of studies that need to be done.

“The only way you can check if a sperm is really viable is if it fertilises an egg and goes on and develops into a baby.”

Professor Harper said most infertile men did produce sperm that can be extracted from their reproductive system as part of specialised treatment.

Kallistem’s new treatment would be for those who do not produce any mature sperm at all, she added, although, in these cases, the resulting cells would have to be checked to ensure they are “genetically normal”.

Spermatogenesis, the process through which basic reproduction cells – the germ cells – develop into sperm cells, is an extremely complex one. It takes about 72 days in the human body. The scientists said their research could help tens of thousands of men.

Infertility affects at least 10 per cent of couples, and in at least a third of cases it relates to male fertility problems, which are often genetic.

The most common defect is missing regions of male Y chromosomes, which is associated with the production of few or no sperm.

Under the new process, experts would be able to extract reproductive cells from a man’s testes and then freeze them until he wishes to father a child, the firm said.

However, Professor Allan Pacey, of the University of Sheffield, urged couples to treat the announcement with caution.

He said: “This is a bold claim to make and we have had our fingers burnt before. Until I see a peer-reviewed scientific publication showing unequivocally that this has been done, I have to remain sceptical.

“Claims like this can often cause heartache for infertile couples who see them as hope only to have their hopes dashed later when it doesn’t translate into an available procedure.”

Kallistem, which is trying to raise funding for its research, will hold preclinical trials until next year and clinical trials in 2017.

“If it works, this procedure opens great prospects,” said Nathalie Rives, the manager of a fertility clinic.

However, like Professor Harper, she warned that adults suffering from a complete lack of sperm might have “genetic anomalies” that could exclude them from the process.

Professor Israel Nisand, co-founder of the European Bioethics Forum, said the procedure was preferable to reproductive cloning.

Previously, lab-created spermatogenesis had been successful only in mice.

Last year, American researchers announced that they had used skin from infertile men to create sperm after the samples were implanted into the testes of mice.

The samples were genetically engineered to assume the properties of embryonic stem cells beforehand.

Telegraph, London

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Henry Sapiecha

WANT TO GET PREGNANT? USE PERUVIAN MACA TO FINE TUNE YOUR HORMONES

Sunday, May 19th, 2013

SOUTH AMERICAN ROOT HERB SAID TO DO WONDERS FOR FERTILITY

Maca (Lepidium meyenii) is a root-like cruciferous vegetable from the Andes of Peru. It grows in some of the harshest farmlands in the world, where the soil is rich in volcanic minerals, experiencing freezing temperatures, fierce winds and intense sunlight . Maca is the only plant known in the world that can grow and thrive at such a high altitude and in such harsh weather. For more than two millennia, native Peruvians have used maca root as food and medicine to promote fertility, endurance, energy, vitality, and sexual virility.

Stories of maca’s fertility supporting effects have been passed down through history in a story that took place in the 1500’s. Soon after the Spanish Conquest in South America occurred the Spanish began to experience poor health and infertility in themselves as well as in their livestock. This was due to the high altitude of the Andes. The native Peruvians recommended that they feed their livestock and themselves maca. The results were so dramatic that many of the first written records ever kept for the Andean region were passages about maca. There are also historical notes recording that the Conquistadors began demanding to be paid in maca instead of gold.

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How Maca Works

Containing 31 different minerals and 60 different phytonutrients, maca is a nourishing food for the endocrine system, aiding both the pituitary, adrenal, and thyroid glands (all involved in hormonal balance.) Maca has the ability to affect key hormones in both women and men without containing hormones itself.

Maca has been scientifically researched for the use of increasing fertility since 1961 and has been shown to contain specific compounds called glucosinolates which directly can affect fertility for both men and women. These alkaloids are responsible for maca’s ability to support hormonal balance.

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Benefits of maca:

  • Supports hormonal balance
  • Increases energy, stamina, and mental clarity
  • Supports the thyroid
  • Supports normal sexual function

Adaptogenic
Maca also has adaptogenic properties which means it helps to strengthen the body so it is able to better resist disease and stress, support the adrenal glands and balances the body’s functions. In order for an herb to be considered an adaptogen it must be non-toxic or harmless to any organ of the body and must be able to be ingested for long periods of time safely. Maca is classified as an adaptogen.

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Endocrine system tonic
One of maca’s main actions is to stimulate and nourish the hypothalamus which regulates the pituitary gland, acting as a tonic for the hormone system. When the pituitary gland functions optimally, the entire endocrine system becomes balanced, because the pituitary gland controls the hormone output of the other three glands.

Promotes Hormonal Balance
In women, maca works by controlling estrogen in the body. Estrogen levels that are high or low at the wrong time can keep a woman from becoming pregnant or keep her from carrying to term. Excess estrogen levels also cause progesterone levels to become too low. Taking maca may help to increase the progesterone levels which are essential to carrying a healthy pregnancy.

Estrogen in men produces erectile dysfunction or lack of libido, low sperm count, and lowered production of seminal fluid. Studies have shown that men who use maca may experience an increased libido and an increase in sperm health.

In one study with rats and maca, it was found that animals given maca powder showed multiple egg follicle maturation in females (important for ovulation) and the males had significantly higher sperm production and motility rates.

Supports normal sexual function
In a human study of 9 men who were given gelatinized maca for 4 months at 1,500 – 3,000 mg a day experienced an increase in libido, sperm count, mobillity of sperm, increased DHEA levels, decreased anxiety and stress, lowered blood pressure, balanced iron levels and an increase in adrenal androgens.

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How to Use Maca

When purchasing maca you want to make sure the product you are using has only maca root in it, not leaves or stem. Maca is available in powder, capsules or tincture. It is also available in varying strengths.

Maca powder: Maca powder comes in two forms. Plain maca powder that is just powdered maca root or gelatinized maca. Gelatinization is a completely vegetarian process that removes the starch from maca to improve assimilation and increases the concentration.

We find that gelatinized maca is easier to digest than the plain powder and is also more cost effective since it is more concentrated. The studies mentioned above used gelatinized maca. Gelatinization does not refer to “gelatin”, and no animal derived ingredients are incorporated into this process.

Maca powder can be added to juice, smoothies, yogurt or baked goods. It has a nice malty flavor which goes well with foods. I like to add it to all of my smoothies.

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Maca capsules: Maca capsules are a convenient way to get maca daily. Many people will find using the maca capsules to be easier since they can be taken at any time with some water.

Maca tincture: A tincture of maca root is a liquid extract of the medicinal properties of maca. Maca tincture is can be taken with water, in juice or added to smoothies.

Dosage
General suggested usage is 2000-3000 mg a day. To obtain desired results, maca needs to be taken regularly. It can be taken in one dose or through out the day.

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Safety & Side Effects

Maca is a beneficial herb that has been used for thousands of years and consumed everyday as a food and medicine by the Peruvians. Based on its long history of use as a food it appears to be very safe. Toxicity studies (conducted at Product Safety Labs of East Brunswick, N.J.) showed absolutely no toxicity and no adverse pharmacological effects.

In a small amount of women, some using plain maca root (not gelatinized) experienced stomach upset. Some women experience spotting or a change in their menstrual cycle when they first begin using maca. This is normal and a sign that the body is beginning to balance the hormonal system.

Maca Use During Pregnancy

As a safety precaution most manufacturers state that their supplements should not be used during pregnancy. There have been no studies on the use of maca during pregnancy. Acute toxicity studies and cytotoxicity evaluations have demonstrated absence of any evidence of potential toxicity of maca. The Peruvians have been consuming maca as a food for thousands of years. Since there have been no studies on the use of maca during pregnancy we can not state that it is proven safe to use during pregnancy. Please do your own research and make a personal decision on the use of maca during your pregnancy.

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Summary

As you can see from all the actions maca can have on the body, it is a wonderful fertility superfood and tonic. Maca can complement any fertility program and should be used on a daily basis for best results. It can also be used in conjunction with other fertility herbs and supplements.

Henry Sapiecha